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Role of astrocytes and microglia in hepatic encephalopathy associated with advanced chronic liver disease:lessons from animal studies

Wouter Claeys Anja Geerts Lien Van Hoecke Christophe Van Steenkiste Roosmarijn E.Vandenbroucke

Neural Regeneration Research2025，Vol.20Issue(12)：P.3461-3475,15.

Neural Regeneration Research2025，Vol.20Issue(12)：P.3461-3475,15.DOI:10.4103/NRR.NRR-D-24-00600

Role of astrocytes and microglia in hepatic encephalopathy associated with advanced chronic liver disease:lessons from animal studies

Wouter Claeys ¹Anja Geerts ²Lien Van Hoecke ³Christophe Van Steenkiste ⁴Roosmarijn E.Vandenbroucke³

作者信息

1. Department of Internal Medicine and Paediatrics,Hepatology Research Unit,Ghent University,Ghent,Belgium Liver Research Center Ghent,Ghent University,Ghent University Hospital,Ghent,Belgium Barriers in Inflammation,VIB-UGent Center for Inflammation Research,VIB,Ghent,Belgium Department of Biomedical Molecular Biology,Ghent University,Ghent,Belgium
2. Department of Internal Medicine and Paediatrics,Hepatology Research Unit,Ghent University,Ghent,Belgium Liver Research Center Ghent,Ghent University,Ghent University Hospital,Ghent,Belgium Department of Gastroenterology and Hepatology,Ghent University Hospital,Ghent,Belgium
3. Barriers in Inflammation,VIB-UGent Center for Inflammation Research,VIB,Ghent,Belgium Department of Biomedical Molecular Biology,Ghent University,Ghent,Belgium
4. Department of Gastroenterology and Hepatology,Antwerp University,Antwerp,Belgium Department of Gastroenterology and Hepatology,Maria Middelares Hospital,Ghent,Belgium
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摘要

关键词

ammonia/astrocytes/cirrhosis/hepatic encephalopathy/microglia/neuroinflammation/osmotic stress/oxidative stress/systemic inflammation

分类

医药卫生

引用本文复制引用

Wouter Claeys,Anja Geerts,Lien Van Hoecke,Christophe Van Steenkiste,Roosmarijn E.Vandenbroucke..Role of astrocytes and microglia in hepatic encephalopathy associated with advanced chronic liver disease:lessons from animal studies[J].Neural Regeneration Research,2025,20(12):P.3461-3475,15.

基金项目

supported by grants from the Research Foundation–Flanders(11A6420N,1268823N to WC and LVH) （11A6420N,1268823N to WC and LVH）

a FWO Junior Research Project Grant(G055121N to REV) （G055121N to REV）

VIB.AG is a senior clinical researcher of the Research Foundation–Flanders(1805718N)。（1805718N）

Neural Regeneration Research

ISSN：1673-5374

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