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Generation,interrogation,and future applications of microglia-containing brain organoids

Julia Di Stefano Federica Di Marco Ilaria Cicalini Una FitzGerald Damiana Pieragostino Marleen Verhoye Peter Ponsaerts Elise Van Breedam

Neural Regeneration Research2025，Vol.20Issue(12)：P.3448-3460,13.

Neural Regeneration Research2025，Vol.20Issue(12)：P.3448-3460,13.DOI:10.4103/NRR.NRR-D-24-00921

Generation,interrogation,and future applications of microglia-containing brain organoids

Julia Di Stefano ¹Federica Di Marco ²Ilaria Cicalini ²Una FitzGerald ³Damiana Pieragostino ²Marleen Verhoye ⁴Peter Ponsaerts ⁵Elise Van Breedam⁵

作者信息

1. Laboratory of Experimental Hematology,Vaccine and Infectious Disease Institute(Vaxinfectio),University of Antwerp,Wilrijk,Belgium Bio-Imaging Lab,University of Antwerp,Wilrijk,Belgium
2. Center for Advanced Studies and Technology(CAST),G.d’Annunzio University of Chieti-Pescara,Chieti,Italy Department of Innovative Technologies in Medicine and Dentistry,University“G.d’Annunzio”of Chieti-Pescara,Chieti,Italy
3. CÚRAM,Center for Research in Medical Devices,Biomedical Engineering,University of Galway,Ireland Galway Neuroscience Center,University of Galway,Ireland
4. Bio-Imaging Lab,University of Antwerp,Wilrijk,Belgium μNEURO Research Center of Excellence,University of Antwerp,Wilrijk,Belgium
5. Laboratory of Experimental Hematology,Vaccine and Infectious Disease Institute(Vaxinfectio),University of Antwerp,Wilrijk,Belgium
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摘要

关键词

3D cell culture/brain organoids/immune response/immunocompetent model/in vitro model/microglia/neural organoids/neuroimmunology/neuroinflammation

分类

医药卫生

引用本文复制引用

Julia Di Stefano,Federica Di Marco,Ilaria Cicalini,Una FitzGerald,Damiana Pieragostino,Marleen Verhoye,Peter Ponsaerts,Elise Van Breedam..Generation,interrogation,and future applications of microglia-containing brain organoids[J].Neural Regeneration Research,2025,20(12):P.3448-3460,13.

基金项目

funded by the European Union’s Horizon 2020 research and innovation programme under the Marie Skodowska-Curie grant agreement No.813263(PMSMat Train,granted to UF,PP,MV,and DP) （PMSMat Train,granted to UF,PP,MV,and DP）

provided by the Fund for Scientific Research Flanders(FWO-Vlaanderen)of the Flemish Government(FWO sabbatical bench fee K800224N granted to PP)and ERA-NET Re Park(granted to PP)。（FWO-Vlaanderen）

Neural Regeneration Research

ISSN：1673-5374

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