A Self-assembled Nanomicelle for Realizing Tumor Photodynamic Therapy via Increasing Drug Accumulation and Prolonging Retention TimeOA北大核心
A nanomicelle(denoted as TPGS/Ppa)was fabricated via the coassembly of the amphiphilic D-α-tocopheryl polyethylene glycol 1000 succinate(TPGS)and the hydrophobic photosensitizer pyropheophorbide a(Ppa)for photodynamic therapy(PDT).The obtained nanomicelle possessed a spherical structure with a diameter of(18.0±2.2)nm and a zeta potential of approximately -18 mV.Besides,the nanomicelle exhibited excellent photostability,biocompatibility,and phototoxicity,and could effectively reach the tumor region via the enhanced permeability and retention effect.Additionally,it could be found that the TPGS/Ppa nanomicelle exhibited higher phototoxicity against 4T1 murine mammary cancer cells than free Ppa.In the 4T1 tumor-bearing mouse model,the nanomicelle showed an excellent antitumor therapeutic effect.This study develops a new type of photodynamic nanomicelle TPGS/Ppa,which can increase the accumulation of drugs and prolong their tumor retention time,providing a feasible strategy for realizing the delivery of small-molecule hydrophobic drugs and tumor PDT.
AN Yaolong;LI Zi-Heng;WU Fu-Gen
State Key Laboratory of Digital Medical Engineering,Key Laboratory for Biomaterials and Devices of Jiangsu Province,School of Biological Science and Medical Engineering,Southeast University,Nanjing 211189,ChinaState Key Laboratory of Digital Medical Engineering,Key Laboratory for Biomaterials and Devices of Jiangsu Province,School of Biological Science and Medical Engineering,Southeast University,Nanjing 211189,ChinaState Key Laboratory of Digital Medical Engineering,Key Laboratory for Biomaterials and Devices of Jiangsu Province,School of Biological Science and Medical Engineering,Southeast University,Nanjing 211189,China
化学
Photodynamic therapyNanodrugPhotosensitizerD-α-Tocopheryl polyethylene glycol 1000 succinateCell apoptosis
《高等学校化学学报》 2025 (1)
P.106-116,11
国家自然科学基金(批准号:82372127)资助.
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