阿尔茨海默病及相关病2025，Vol.8Issue(1)：29-35,7.DOI:10.3969/j.issn.2096-5516.2025.01.005
轻度认知障碍高效认知筛查量表CQ-MCI的探索研究
CQ-MCI:a potential efficient cognitive screeningscale for mild cognitive impairment
摘要
Abstract
Objective:Mild cognitive impairment(MCI)represents a crucial stage in the early diagnosis and intervention of dementia.MCI due to AD is the main type of MCI.Using a single cognitive screening scale for MCI has some shortcomings such as limited sensitivity and specificity.Meanwhile,using a comprehensive neuropsychological battery for MCI screening is time consuming and laborintensive.Therefore,this study aims to explore an efficient cognitive screening scale for Chinese population of MCI due to AD,based on previously used cognitive assessment tools.Methods:A total of 27 cognitive screening tests and the Clinical Dementia Rating(CDR)scale were administered to 242 participants:121 in the control group(CDR=0)and 121 in the MCI group(CDR=0.5).Spearman correlation analysis was used to assess the relationship between Z scores of each test and CDR scores.Tests showing significant correlations were used to construct a new screening scale for MCI.Then conduct a preliminary analysis of the sensitivity and specificity of the new scale,and establish the scoring criteria for the new scale.Results:The results of the correlation analysis showed that among the neuropsychological tests in various cognitive domains,Visual Cognitive Assessment Test(VCAT)-Language(r=-0.447,P<0.001),VCAT-Memory(r=-0.717,P<0.001),Trail Making Test(TMT)-B(r=0.426,P<0.001),Mini-Mental State Examination(MMSE)-Orientation(r=-0.271,P=0.025),MMSE-Attention(r=-0.313,P=0.009),and Clock Drawing Test(CDT)(r=-0.407,P<0.001)had the strongest correlations with CDR scores.These six cognitive tests were used to construct a new scale.And pass/fail criteria was derived that determined"possible"(one test failed),"probable"(two tests failed),and"definite"MCI(three tests failed).Conclusion:VCAT-Language;VCAT-Memory,TMT-B,MMSE-Orientation,MMSE-Attention,and CDT tests can be integrated to form a new screening scale for MCI suitable for the Chinese population of MCI due to AD.Further clinical validation is needed in the future to assess the sensitivity and feasibility of CQ-MCI.关键词
轻度认知障碍/神经心理学量表/筛查量表Key words
Mild cognitive impairment/Neuropsychological test/Screening scale分类
医药卫生引用本文复制引用
廖紫璇,李佳钰,刘一丹,黄述春,姜柳米,李小凤..轻度认知障碍高效认知筛查量表CQ-MCI的探索研究[J].阿尔茨海默病及相关病,2025,8(1):29-35,7.基金项目
重庆医科大学附属第二医院"宽仁英才"骨干项目(项目编号:2020-7-3-17) （项目编号:2020-7-3-17）
重庆市卫生健康委医学科研项目(项目编号:2023WSJK118) （项目编号:2023WSJK118）
