环境与职业医学2024，Vol.41Issue(12)：1349-1353,1360,6.DOI:10.11836/JEOM24442
环境新污染物毒效应中芳香烃受体的作用
Role of aryl hydrocarbon receptor in toxic effects of emerging environmental pollutants
摘要
Abstract
In recent years,an increasing number of emerging environmental pollutants have been identified,garnering widespread attention.Many of these pollutants are characterized by their environmental persistence and bioaccumulation,which pose significant threats to both the eco-logical environment and human health.However,the molecular mechanisms underlying their ef-fects remain unclear,limiting our ability to assess their adverse impacts and develop effective protective measures.The aryl hydrocarbon receptor(AHR)is a ligand-activated transcription factor traditionally known to be activated by dioxins and polycyclic aromatic hydrocarbons(PAHs)and is involved in the metabolism of exogenous chemicals.Recent research has shown that the AHR can be activated by a diverse range of exogenous and endogenous chemicals and participates in various biological processes.Studies have demonstrated that AHR mediates the toxic effects of emerging environmental pollutants such as perfluorooctane sulfonamide(PFOSA)and N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone(6PPDQ).This paper provided an overview of the AHR activation and the toxic effects induced by emerging environmental pollu-tants,with a focus on how the AHR activation interacts with multiple signaling pathways.The significance of these interactions in environmental risk assessment and toxicological research was also discussed.We aim to provide a scientific basis for environmental protection and risk as-sessment.关键词
芳香烃受体/环境新污染物/毒作用机制Key words
aryl hydrocarbon receptor/emerging environmental contaminant/toxic effect分类
医药卫生引用本文复制引用
张明轩,付保强,黎金浩,王康,姜岩,陈涛..环境新污染物毒效应中芳香烃受体的作用[J].环境与职业医学,2024,41(12):1349-1353,1360,6.基金项目
国家自然科学基金项目(81972999) （81972999）
