环境与职业医学2024，Vol.41Issue(12)：1438-1445,8.DOI:10.11836/JEOM24273
全氟及多氟烷基化合物母婴暴露水平及对甲状腺功能影响的作用机制研究进展
Review on per-and polyfluoroalkyl substances exposure,thyroid function,and mechanisms of action in mothers and infants
摘要
Abstract
Due to the outstanding hydrophobic and oleophobic properties,per-and polyfluoroalkyl substances(PFAS)are widely used in daily life and frequently detected in the environment.PFAS can enter the human body through water,food,and air exposure and accumulate in the human body.Epidemiological and toxicological evidence suggest that PFAS have endocrine-disrupting properties and may cause thyroid dysfunction by altering the hormonal homeostasis of the thy-roid.This in turn affects the body's normal physiological functions,such as the physical growth and neurodevelopment in infants.Pregnancy and early life are special physiological stages,and the special dietary and lifestyle habits of this period make mothers and infants more likely to be exposed to PFAS and more susceptible to PFAS.Therefore,the exposure levels of PFAS and their effects on the thyroid function of mothers and infants were summarized in this review.Possible mechanisms of action by which PFAS may affect thyroid function were also summarized,aiming to provide a theoretical basis for the development of environmental standards and safety limits for PFAS.关键词
全氟及多氟烷基化合物/甲状腺/机制/母婴Key words
per-and polyfluoroalkyl substances/thyroid/mechanism of action/maternal and infant分类
医药卫生引用本文复制引用
龚乐敏,卢忠武,周钰涵..全氟及多氟烷基化合物母婴暴露水平及对甲状腺功能影响的作用机制研究进展[J].环境与职业医学,2024,41(12):1438-1445,8.基金项目
国家自然科学基金项目(82304103) （82304103）
2023年上海高校青年教师培养资助计划项目(A2-0202-24-0004-020) （A2-0202-24-0004-020）
