环境与职业医学2024，Vol.41Issue(12)：1446-1451,6.DOI:10.11836/JEOM24197
邻苯二甲酸酯暴露与围产期抑郁发生风险关系的研究进展
Advances on relationship between phthalate exposure and perinatal depression
许月明 1赵梅 1黄以超 2于玲玲 1耿兰 1陈磊1
作者信息
- 1. 安徽医科大学 护理学院,安徽 合肥 230032
- 2. 安徽医科大学公共卫生学院,安徽 合肥 230032
- 折叠
摘要
Abstract
Perinatal depression is a psychological disorder that occurs during pregnancy and within one year of delivery,which can seriously affect the physical and mental health of pregnant and postpartum women,as well as the cognitive and behavioral abilities of offspring,with potential multigenerational effects.Therefore,it is important to identify its potential modifiable risk fac-tors.Phthalic acid esters(PAEs),as common environmental endocrine disruptors,can affect ma-ternal estrogen through multiple mechanisms and are important potential modifiable risk factors for developing maternal perinatal depression.At present,studies on the correlation between PAEs and perinatal depression are still very limited,and the mechanisms by which PAEs affect perinatal depression have not been clarified.Based on existing epidemiological and toxicological studies at home and abroad,the article briefly introduced the characteristics of multiple path-ways,high doses,and long-term exposure to maternal PAEs,focused on reviewing the current status of epidemiological studies,pointed out the possible associations between some specific PAEs exposure and elevated risk of perinatal depression.It also summarized the potential roles of hormone-neurotransmitter pathway,inflammation mediation,gene regulation,and other possible mechanisms in the association between exposure to PAEs and perinatal depression.The article concluded with a look at how future research on the association between exposure to PAEs and perinatal depression can be scientifically validated,with a view to providing more high-quality evidence for the scientific prevention of the onset and progression of maternal depressive symptoms.关键词
邻苯二甲酸酯/孕产妇/围产期抑郁/暴露/生物学机制Key words
phthalic acid esters/maternal/perinatal depression/exposure/biological mechanism分类
医药卫生引用本文复制引用
许月明,赵梅,黄以超,于玲玲,耿兰,陈磊..邻苯二甲酸酯暴露与围产期抑郁发生风险关系的研究进展[J].环境与职业医学,2024,41(12):1446-1451,6.
