基于"少火生气,壮火食气"理论探析2型糖尿病进程中胰岛巨噬细胞对β细胞功能变化的影响OA北大核心

This study examined the effect of islet macrophages on β-cell function changes during type 2 diabetes mellitus(T2DM)progression based on the traditional Chinese medicine theory that"moderate fire generating qi,hyperactive fire consuming qi".T2DM is closely associated with chronic low-grade inflammation,with islet macrophages playing a central role in this process.Under physiological conditions,islet macrophages secrete anti-inflammatory and growth factors to regulate the immune response,promote cell proliferation,and support islet β-cell survival and function,reflecting the concept of"moderate fire generating qi".However,during the pathological process of T2DM,islet macrophages become over-activated and dysfunctional,secreting large amounts of pro-inflammatory factors that trigger severe inflammatory responses and oxidative stress.This process damages islet β-cells,disrupts the islet microenvironment and blood supply,exacerbates local inflammation and structural damage,and worsens the survival environment of β-cells.Ultimately,this leads to fewer β-cells and function loss,aligning with the"hyperactive fire consuming qi"theory,where excessive fire depletes qi and blood.This study enhances the understanding and application of traditional Chinese medicine theories in modern medicine,offering a new perspective on T2DM prevention and treatment.Regulating islet macrophage function and reducing their pro-inflammatory responses may become key strategies for preserving β-cell function and slowing T2DM progression.