北京中医药大学学报2025，Vol.48Issue(1)：14-20,7.DOI:10.3969/j.issn.1006-2157.2025.01.003
基于"少火生气,壮火食气"理论探析2型糖尿病进程中胰岛巨噬细胞对β细胞功能变化的影响
Effect of islet macrophages on β-cell function changes during type 2 diabetes mellitus progression based on the"moderate fire generating qi,hyperactive fire consuming qi"theory
摘要
Abstract
This study examined the effect of islet macrophages on β-cell function changes during type 2 diabetes mellitus(T2DM)progression based on the traditional Chinese medicine theory that"moderate fire generating qi,hyperactive fire consuming qi".T2DM is closely associated with chronic low-grade inflammation,with islet macrophages playing a central role in this process.Under physiological conditions,islet macrophages secrete anti-inflammatory and growth factors to regulate the immune response,promote cell proliferation,and support islet β-cell survival and function,reflecting the concept of"moderate fire generating qi".However,during the pathological process of T2DM,islet macrophages become over-activated and dysfunctional,secreting large amounts of pro-inflammatory factors that trigger severe inflammatory responses and oxidative stress.This process damages islet β-cells,disrupts the islet microenvironment and blood supply,exacerbates local inflammation and structural damage,and worsens the survival environment of β-cells.Ultimately,this leads to fewer β-cells and function loss,aligning with the"hyperactive fire consuming qi"theory,where excessive fire depletes qi and blood.This study enhances the understanding and application of traditional Chinese medicine theories in modern medicine,offering a new perspective on T2DM prevention and treatment.Regulating islet macrophage function and reducing their pro-inflammatory responses may become key strategies for preserving β-cell function and slowing T2DM progression.关键词
2型糖尿病/胰岛巨噬细胞/胰岛β细胞/少火生气/壮火食气Key words
type 2 diabetes mellitus/islet macrophages/islet β-cells/moderate fire generating qi/hyperactive fire consuming qi分类
医药卫生引用本文复制引用
张钰莹,黄薇宇,袁颢瑜,王保华,李赛美..基于"少火生气,壮火食气"理论探析2型糖尿病进程中胰岛巨噬细胞对β细胞功能变化的影响[J].北京中医药大学学报,2025,48(1):14-20,7.基金项目
国家自然科学基金青年基金项目(No.82104791) （No.82104791）
广东省基础与应用基础研究基金面上项目(No.21202104030001057) National Natural Science Foundation of China(No.82104791) （No.21202104030001057）
