现代中医临床2025，Vol.32Issue(1)：15-20,6.DOI:10.3969/j.issn.2095-6606.2025.01.002
肝豆灵片联合奥拉西坦注射液对Wilson病患者认知障碍的影响
The effect of Gandouling Tablets combined with Oxiracetam Injection on cognitive impairment in patients with Wilson's disease
摘要
Abstract
Objective To analyze the risk factors of cognitive impairment in Wilson's disease(WD)and observe the clinical efficacy of Gandouling Tablets combined with Oxiracetam Injection in the treatment of cognitive impairment in WD.Methods 108 patients with WD were divided into the cognitive impairment group and the non-cognitive impairment group.The general data of the two groups were compared,and logistic regression analysis was used to analyze the risk factors for WD cognitive impairment.The 48 patients with cognitive impairment were divided into the Oxiracetam group and the combination therapy group.On the basis of routine treatment,the two groups of patients were given Oxiracetam Injection and Ganduling Tablets combined with Oxiracetam Injection.After 3 consecutive courses of use,the MMSE,MoCA,and ADL scores of the patients were evaluated.Results 1)The incidence rate of cognitive impairment in WD patients was 44.44%,of which 62.50%were mild cognitive impairment,29.17%moderate,and 8.33%severe.(2)UWDRS score,and serum copper levels are independent risk factors for cognitive impairment in WD,while UA levels are a protective factor.(3)The MMSE score,MoCA score,and ADL score of the Oxiracetam group and the combination therapy group both improved compared to before treatment,and the score of the combination therapy group improved more significantly,with statistical differences compared to the Oxiracetam group.Conclusion The incidence rate of cognitive impairment in WD is high,with mild to moderate cognitive impairment as the main factor.Disease severity,serum copper levels,and uric acid levels are influencing factors for cognitive impairment in WD.The combination of Gandouling Tablets and Oxiracetam Injection has significant therapeutic efficacy on cognitive impairment in WD.关键词
Wilson病/认知损害/危险因素/肝豆灵片/奥拉西坦注射液Key words
Wilson's disease/cognitive impairment/risk factors/Gandouling Tablets/Oxiracetam Injection分类
中医学引用本文复制引用
黄晓峰,谢道俊,张娟..肝豆灵片联合奥拉西坦注射液对Wilson病患者认知障碍的影响[J].现代中医临床,2025,32(1):15-20,6.基金项目
国家自然科学基金项目(No.81874389) （No.81874389）
