分析化学2025，Vol.53Issue(1)：14-26,13.DOI:10.19756/j.issn.0253-3820.241434
肿瘤边界成像驱动的分子探针研究进展
Research Progress of Molecular Probes Driven by Tumor Boundary Imaging
摘要
Abstract
″Boundarics in biomedicine″(or″Biomedical boundarics″)is an emerging frontier interdisciplinary subject that focuses on addressing key scientific issues related to the formation,identification,and evolution of biological boundaries within living organisms.In this field,the study of tumor boundaries is of particular importance.Imaging tumor boundaries not only helps to reveal the molecular mechanisms of tumor boundary evolution and interaction with the microenvironment,tumor invasion and metastasis,but is also crucial for clinical tumor diagnosis,treatment decision-making,efficacy monitoring and prognosis evaluation.Molecular probes,as functional substances that enhance imaging signals,play a crucial role in tumor boundary recognition.In this article,the basic concepts and research significance of boundarics in biomedicine and tumor boundarics in biomedicine were summarized firstly.Then a comprehensive review of the research progress in tumor boundary imaging molecular probes was provided,covering areas such as magnetic imaging,optical imaging,acoustic imaging,nuclear imaging,and multimodal imaging.The strategies to regulate the sensitivity,specificity,and safety of molecular probes through chemical structure modifications,conjugation with targeting ligands,and tumor microenvironment-responsive designs were emphasized.Finally,the research trends of molecular probes for tumor boundary imaging were analyzed,and the challenges faced in this field and the future research directions were discussed.关键词
边界生物医学/生物医学边界学/肿瘤边界/分子探针/磁学成像/光学成像/声学成像/核素成像/评述Key words
Boundarics in biomedicine/Biomedical boundarics/Tumor boundary/Molecular probes/Magnetic imaging/Optical imaging/Acoustic imaging/Nuclear imaging/Review引用本文复制引用
任文智,李娟,姚俊列,邢洁,鲍红英,孙犁,吴爱国..肿瘤边界成像驱动的分子探针研究进展[J].分析化学,2025,53(1):14-26,13.基金项目
国家自然科学基金项目(Nos.32025021,T2222021,32171359)、浙江省科技厅项目(No.2020C03110)和宁波市科技局项目(Nos.2020Z094,2023Z189)资助. Supported by the National Natural Science Foundation of China(Nos.32025021,T2222021,32171359),the Zhejiang Provincial Department of Science and Technology(No.2020C03110),and the Ningbo Science and Technology Bureau(Nos.2020Z094,2023Z189). （Nos.32025021,T2222021,32171359）
