分析化学2025，Vol.53Issue(1)：38-46,9.DOI:10.19756/j.issn.0253-3820.241295
多次反射飞行时间质谱仪高性能矩形离子阱的研制
Development of A High-performance Rectangular Ion Trap for Multi-reflection Time-of-Flight Mass Spectrometer
摘要
Abstract
As a new generation of time-of-flight mass spectrometry,multiple-reflection time-of-flight mass spectrometry(MR-TOF-MS)has been increasingly applied in the fields such as nuclear physics,chemistry,and biology due to its ultra-high resolution and rapid analysis capabilities.However,the analytical performance of MR-TOF-MS largely depends on the ion bunch state entering the mass analyzer.In this study,a rectangular ion trap(RIT)was developed,designed and processed using printed circuit board technology,as an ion accumulating and focusing device for MR-TOF mass analyzer.Compared to traditional ion traps composed of two sets of planar electrodes,this RIT had higher voltage utilization efficiency,resulting in more efficient ion collection and focusing.The ions were cooled to a sufficiently small bunch for precise mass measurement with MR-TOF-MS mass spectrometry in only 1 ms of cooling time in the RIT,then orthogonally ejected to the MR-TOF mass spectrometer for mass analysis.Experimental results indicated that the working cycle,ion flux,and ion focusing state of the RIT fully met the requirements of the MR-TOF mass analyzer.When coupled with the MR-TOF mass analyzer,the RIT enabled MR-TOF-MS to achieve a mass resolution of 1.5×105.关键词
矩形离子阱/离子传输/质量范围/质量分辨率/多次反射飞行时间质谱Key words
Rectangular ion trap/Ion transport/Mass range/Mass resolution/Multiple-reflection time-of-flight mass spectrometry引用本文复制引用
陈小霞,徐经纬,周振,任熠,黄奇,向大军,李长伟,洪义,李磊,黄正旭,李梅..多次反射飞行时间质谱仪高性能矩形离子阱的研制[J].分析化学,2025,53(1):38-46,9.基金项目
国家自然科学基金项目(No.41827804)资助. Supported by the National Natural Science Foundation of China(No.41827804). （No.41827804）
