分析化学2025，Vol.53Issue(1)：47-54,8.DOI:10.19756/j.issn.0253-3820.241373
用于小分子物质的转弯型无损离子操纵结构的研究
Research on Turning Structures for Lossless Ion Manipulations of Small Molecules
摘要
Abstract
Travelling wave structures for lossless ion manipulations(TW-SLIM)employ travelling wave electric fields to propel ions forward,enabling exceptionally long transmission paths and holding great potential for applications in material transportation and separation.In this study,different from previous studies focusing on the transport performance of macromolecules such as proteins in TW-SLIM,the transmission performance of small molecules(<200 amu)was investigated and analyzed in the turning TW-SLIM through the COMSOL simulation platform,to explore the influence of electrostatic field of protective electrode and radio frequency(RF)electric field on ion transport efficiency,and obtain the optimal value.Compared to macromolecules,small molecules required lower voltage amplitudes from guard electrodes but stricter requirements in terms of the peak-to-peak amplitude and frequency of RF voltage for lossless transmission.Using dimethyl methylphosphonate(DMMP)as a sample and testing it on the TW-SLIM experimental platform,when the protective voltage amplitude was 5 V and the peak-to-peak voltage of the radio-frequency electrode was 440 V at 1.5 MHz,the ion transmission efficiency reached 100%,achieving lossless transmission.The experimental results provided valuable references for application of TW-SLIM in separation and detection of small molecular substances,such as explosives and drugs.关键词
无损离子操纵结构/行波结构/离子迁移谱/小分子Key words
Structures for lossless ion manipulations/Traveling wave/Ion mobility spectrometry/Small molecules引用本文复制引用
刘青,彭前,张允晶,李灵锋,何兴理,李鹏..用于小分子物质的转弯型无损离子操纵结构的研究[J].分析化学,2025,53(1):47-54,8.基金项目
国家自然科学基金项目(Nos.62001318,21904091)资助. Supported by the National Natural Science Foundation of China(Nos.62001318,21904091). （Nos.62001318,21904091）
