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Spatial multiplexed immunofluorescence analysis reveals coordinated cellular networks associated with overall survival in metastatic osteosarcoma

Ryan A.Lacinski Kurt R.Weiss Brock A.Lindsey Sebastian A.Dziadowicz Vincent K.Melemai Brody Fitzpatrick John J.Pisquiy Tanya Heim Ines Lohse Karen E.Schoedel Nicolas J.Llosa

骨研究(英文版)2024,Vol.12Issue(4):877-894,18.
骨研究(英文版)2024,Vol.12Issue(4):877-894,18.DOI:10.1038/s41413-024-00359-z

Spatial multiplexed immunofluorescence analysis reveals coordinated cellular networks associated with overall survival in metastatic osteosarcoma

Spatial multiplexed immunofluorescence analysis reveals coordinated cellular networks associated with overall survival in metastatic osteosarcoma

Ryan A.Lacinski 1Kurt R.Weiss 2Brock A.Lindsey 3Sebastian A.Dziadowicz 4Vincent K.Melemai 5Brody Fitzpatrick 5John J.Pisquiy 5Tanya Heim 2Ines Lohse 2Karen E.Schoedel 6Nicolas J.Llosa3

作者信息

  • 1. Department of Orthopaedics,West Virginia University School of Medicine,Morgantown,WV 26506,USA||Cancer Institute,West Virginia University School of Medicine,Morgantown,WV 26506,USA
  • 2. Department of Orthopaedic Surgery,University of Pittsburgh Medical Center,Pittsburgh,PA 15213,USA
  • 3. Department of Orthopaedic Surgery,Johns Hopkins University School of Medicine,Baltimore,MD 21287,USA
  • 4. Department of Microbiology,Immunology and Cell Biology,West Virginia University School of Medicine,Morgantown,WV 26506,USA||Bioinformatics Core,West Virginia University School of Medicine,Morgantown,WV 26506,USA
  • 5. Department of Orthopaedics,West Virginia University School of Medicine,Morgantown,WV 26506,USA
  • 6. Department of Pathology,University of Pittsburgh Medical Center,Pittsburgh,PA 15213,USA
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摘要

引用本文复制引用

Ryan A.Lacinski,Kurt R.Weiss,Brock A.Lindsey,Sebastian A.Dziadowicz,Vincent K.Melemai,Brody Fitzpatrick,John J.Pisquiy,Tanya Heim,Ines Lohse,Karen E.Schoedel,Nicolas J.Llosa..Spatial multiplexed immunofluorescence analysis reveals coordinated cellular networks associated with overall survival in metastatic osteosarcoma[J].骨研究(英文版),2024,12(4):877-894,18.

基金项目

We acknowledge Amisha Dhawn(staining,image acquisition),Katrina Evans(quality assessment,technical support),and Yue Hou(training,bioinformatics)of the Akoya Biosciences Spatial Tissue Exploration Program for their support of this work.We also acknowledge the Enable Medicine team,particularly Ying Qu,for technical support during analysis of this work.We acknowledge Tony Green and the University of Pittsburgh Biospecimen Core for their efforts in the creation of the tissue microarrays analyzed here.This project used the UPMC Hillman Cancer Center and Tissue and Research Pathology/Pitt Biospecimen Core shared resource,which is supported,in part,by award P30CA047904.This work was supported through grant funding by the Pittsburgh Cure Sarcoma Foundation and internal funding by the West Virginia University School of Medicine,Department of Orthopaedics. (staining,image acquisition)

骨研究(英文版)

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2095-4700

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