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Mapping RANKL-and OPG-expressing cells in bone tissue:the bone surface cells as activators of osteoclastogenesis and promoters of the denosumab rebound effect

Bilal M.El-Masri Lars J.Hansen Albert S.Kim Victoria E.Taylor Caitlyn Massarotti Michelle M.McDonald Xiaomeng You Julia F.Charles Jean-Marie Delaisse Thomas L.Andersen Christina M.Andreasen Kaja S.Laursen Viktoria B.Kofod Xenia G.Dahl Malene H.Nielsen Jesper S.Thomsen Annemarie Brüel Mads S.Sørensen

骨研究（英文版）2024，Vol.12Issue(4)：912-932,21.

骨研究（英文版）2024，Vol.12Issue(4)：912-932,21.DOI:10.1038/s41413-024-00362-4

Mapping RANKL-and OPG-expressing cells in bone tissue:the bone surface cells as activators of osteoclastogenesis and promoters of the denosumab rebound effect

Bilal M.El-Masri ¹Lars J.Hansen ²Albert S.Kim ³Victoria E.Taylor ³Caitlyn Massarotti ³Michelle M.McDonald ⁴Xiaomeng You ⁵Julia F.Charles ⁵Jean-Marie Delaisse ¹Thomas L.Andersen ⁶Christina M.Andreasen ⁷Kaja S.Laursen ⁸Viktoria B.Kofod ¹Xenia G.Dahl ¹Malene H.Nielsen ⁹Jesper S.Thomsen ¹⁰Annemarie Brüel ¹⁰Mads S.Sørensen²

作者信息

1. Department of Clinical Research,University of Southern Denmark,Odense,Denmark||Danish Spatial Imaging Consortium,University of Southern Denmark,Odense,Denmark
2. Department of Otorhinolaryngology-Head and Neck Surgery and Audiology,University Hospital of Copenhagen,Rigshospitalet,Copenhagen,Denmark
3. Skeletal Diseases Program,Garvan Institute of Medical Research,Sydney,NSW,Australia
4. Skeletal Diseases Program,Garvan Institute of Medical Research,Sydney,NSW,Australia||Cancer Theme,School of Medical Sciences,Faculty of Medicine and Health,The University of Sydney,Sydney,Australia
5. Department of Orthopedic Surgery,Brigham and Women's Hospital,Harvard Medical School,Boston,MA,USA
6. Department of Clinical Research,University of Southern Denmark,Odense,Denmark||Danish Spatial Imaging Consortium,University of Southern Denmark,Odense,Denmark||Department of Pathology,Odense University Hospital,Odense,Denmark||Department of Forensic Medicine,Aarhus University,Aarhus,Denmark
7. Department of Clinical Research,University of Southern Denmark,Odense,Denmark||Danish Spatial Imaging Consortium,University of Southern Denmark,Odense,Denmark||Department of Pathology,Odense University Hospital,Odense,Denmark
8. Department of Forensic Medicine,Aarhus University,Aarhus,Denmark
9. Danish Spatial Imaging Consortium,University of Southern Denmark,Odense,Denmark||Department of Pathology,Odense University Hospital,Odense,Denmark
10. Department of Biomedicine,Aarhus University,Aarhus,Denmark
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摘要

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Bilal M.El-Masri,Lars J.Hansen,Albert S.Kim,Victoria E.Taylor,Caitlyn Massarotti,Michelle M.McDonald,Xiaomeng You,Julia F.Charles,Jean-Marie Delaisse,Thomas L.Andersen,Christina M.Andreasen,Kaja S.Laursen,Viktoria B.Kofod,Xenia G.Dahl,Malene H.Nielsen,Jesper S.Thomsen,Annemarie Brüel,Mads S.Sørensen..Mapping RANKL-and OPG-expressing cells in bone tissue:the bone surface cells as activators of osteoclastogenesis and promoters of the denosumab rebound effect[J].骨研究（英文版）,2024,12(4):912-932,21.

基金项目

We thank Søren Harving for providing the investigated human bone specimens,and Birgit MacDonald,Signe Marie Andersen,and Ariel Castro-Martinez for their technical contributions.The study was supported by Odense University Hospital's Fund for Free Research(A5111),the Region of Southern Denmark's Fund for Free Research(A955),and the VELUX Foundations(VELUX25723).The study was supported by the Novo Nordisk Foundation.Amgen Inc provided the OPG:Fc under a material transfer agreement. （A5111）

骨研究（英文版）

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ISSN：2095-4700

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