首页|期刊导航|骨研究（英文版）|IRF1-mediated upregulation of PARP12 promotes cartilage degradation by inhibiting PINK1/Parkin dependent mitophagy through ISG15 attenuating ubiquitylation and SUMOylation of MFN1/2

IRF1-mediated upregulation of PARP12 promotes cartilage degradation by inhibiting PINK1/Parkin dependent mitophagy through ISG15 attenuating ubiquitylation and SUMOylation of MFN1/2

Zengfa Deng Yan Kang Guping Mao Dianbo Long Changzhao Li Hailong Liu Wei Li Yanlin Zhong Xiaolin Mo Ruiyun Li Zibo Yang

骨研究（英文版）2024，Vol.12Issue(4)：933-951,19.

骨研究（英文版）2024，Vol.12Issue(4)：933-951,19.DOI:10.1038/s41413-024-00363-3

IRF1-mediated upregulation of PARP12 promotes cartilage degradation by inhibiting PINK1/Parkin dependent mitophagy through ISG15 attenuating ubiquitylation and SUMOylation of MFN1/2

Zengfa Deng ¹Yan Kang ²Guping Mao ²Dianbo Long ²Changzhao Li ³Hailong Liu ³Wei Li ²Yanlin Zhong ²Xiaolin Mo ²Ruiyun Li ⁴Zibo Yang²

作者信息

1. Department of Sports Medicine,the First Affiliated Hospital,Sun Yat-sen University,Guangzhou,Guangdong 510080,China||Guangdong Provincial Key Laboratory of Orthopedics and Traumatology,the First Affiliated Hospital,Sun Yat-sen University,Guangzhou,Guangdong 510080,China||Department of Joint Surgery and Sports Medicine,Center for Orthopedic Surgery,The Third Affiliated Hospital of Southern Medical University,Guangzhou,Guangdong,China
2. Department of Sports Medicine,the First Affiliated Hospital,Sun Yat-sen University,Guangzhou,Guangdong 510080,China||Guangdong Provincial Key Laboratory of Orthopedics and Traumatology,the First Affiliated Hospital,Sun Yat-sen University,Guangzhou,Guangdong 510080,China
3. Department of Joint Surgery,the First Affiliated Hospital,Sun Yat-sen University,Guangzhou,Guangdong,510080,China
4. Department of Anesthesiology,Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences),Southern Medical University,Guangzhou,China
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摘要

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Zengfa Deng,Yan Kang,Guping Mao,Dianbo Long,Changzhao Li,Hailong Liu,Wei Li,Yanlin Zhong,Xiaolin Mo,Ruiyun Li,Zibo Yang..IRF1-mediated upregulation of PARP12 promotes cartilage degradation by inhibiting PINK1/Parkin dependent mitophagy through ISG15 attenuating ubiquitylation and SUMOylation of MFN1/2[J].骨研究（英文版）,2024,12(4):933-951,19.

基金项目

This study was supported by the National Natural Science Foundation of China(82202739),Guangdong Basic and Applied Basic Research Foundation Natural Science Fund Project-Youth Promotion Project(2024A1515030260),China State-funded Postdoctoral Researchers Program(GZC20233265),National Natural Science Foundation of China(81972051). （82202739）

骨研究（英文版）

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