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DNMT aberration-incurred GPX4 suppression prompts osteoblast ferroptosis and osteoporosis

Binjia Ruan Hongwei Wang Yongxiang Wang Jian Dong Fanhao Wei Zhiqiang Huang Bin Yang Lijun Zhang Chuling Li Hui Dong Wangsen Cao

骨研究(英文版)2024,Vol.12Issue(4):966-979,14.
骨研究(英文版)2024,Vol.12Issue(4):966-979,14.DOI:10.1038/s41413-024-00365-1

DNMT aberration-incurred GPX4 suppression prompts osteoblast ferroptosis and osteoporosis

DNMT aberration-incurred GPX4 suppression prompts osteoblast ferroptosis and osteoporosis

Binjia Ruan 1Hongwei Wang 2Yongxiang Wang 1Jian Dong 3Fanhao Wei 1Zhiqiang Huang 2Bin Yang 1Lijun Zhang 2Chuling Li 4Hui Dong 1Wangsen Cao5

作者信息

  • 1. Department of Orthopedics,Northern Jiangsu People's Hospital,Clinical Teaching Hospital of Medical School,Nanjing University,98 West Nantong Road,Yangzhou 225001,China
  • 2. Nanjing University Medical School,Jiangsu Key Laboratory of Molecular Medicine&State Key Laboratory of Analytical Chemistry for Life Science,22 Hankou Road,Nanjing 210093,China
  • 3. Department of Thoracic Surgery,Nanjing Drum Tower Hospital,The Affiliated Hospital of Medical School,Nanjing University,Nanjing,Jiangsu 210008,China
  • 4. Department of Respiratory Medicine,Jinling Hospital,Affiliated Hospital of Nanjing University Medical School,305 East Zhongshan Road,Nanjing 210002,China
  • 5. Department of Orthopedics,Northern Jiangsu People's Hospital,Clinical Teaching Hospital of Medical School,Nanjing University,98 West Nantong Road,Yangzhou 225001,China||Nanjing University Medical School,Jiangsu Key Laboratory of Molecular Medicine&State Key Laboratory of Analytical Chemistry for Life Science,22 Hankou Road,Nanjing 210093,China
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摘要

引用本文复制引用

Binjia Ruan,Hongwei Wang,Yongxiang Wang,Jian Dong,Fanhao Wei,Zhiqiang Huang,Bin Yang,Lijun Zhang,Chuling Li,Hui Dong,Wangsen Cao..DNMT aberration-incurred GPX4 suppression prompts osteoblast ferroptosis and osteoporosis[J].骨研究(英文版),2024,12(4):966-979,14.

基金项目

This work was supported by the National Key Research and Development Program of China(2023YFB3810200,2023YFB3810204,2022YFF0710801),the National Natural Science Foundation of China(82470749,82370899,82272502,82072423). (2023YFB3810200,2023YFB3810204,2022YFF0710801)

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