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Bone loss with aging is independent of gut microbiome in mice

Xiaomeng You Melissa A.Kacena Nabarun Chakraborty Julia F.Charles Jing Yan Jeremy Herzog Sabah Nobakhti Ross Campbell Allison Hoke Rasha Hammamieh R.Balfour Sartor Sandra Shefelbine

骨研究（英文版）2024，Vol.12Issue(4)：980-993,14.

骨研究（英文版）2024，Vol.12Issue(4)：980-993,14.DOI:10.1038/s41413-024-00366-0

Bone loss with aging is independent of gut microbiome in mice

Xiaomeng You ¹Melissa A.Kacena ²Nabarun Chakraborty ³Julia F.Charles ⁴Jing Yan ¹Jeremy Herzog ⁵Sabah Nobakhti ⁶Ross Campbell ⁷Allison Hoke ⁸Rasha Hammamieh ³R.Balfour Sartor ⁵Sandra Shefelbine⁶

作者信息

1. Department of Orthopaedic Surgery,Brigham and Women's Hospital,Harvard Medical School,Boston,MA 02115,USA
2. Department of Orthopaedic Surgery,Indiana University School of Medicine,Indianapolis,IN 46202,USA||Richard L.Roudebush VA Medical Center,Indianapolis,IN 46202,USA
3. Medical Readiness Systems Biology,Walter Reed Army Institute of Research,Silver Spring,MD 20910,USA
4. Department of Orthopaedic Surgery,Brigham and Women's Hospital,Harvard Medical School,Boston,MA 02115,USA||Division of Rheumatology,Brigham and Women's Hospital,Harvard Medical School,Boston,MA 02115,USA
5. National Gnotobiotic Rodent Resource Center,Center for Gastrointestinal Biology and Disease,University of North Carolina at Chapel Hill,Chapel Hill,NC 27599,USA
6. Department of Mechanical and Industrial Engineering,Northeastern University,Boston,MA 02115,USA
7. The Geneva Foundation,Walter Reed Army Institute of Research,Silver Spring,MD 20910,USA||Medical Readiness Systems Biology,Walter Reed Army Institute of Research,Silver Spring,MD 20910,USA
8. Medical Readiness Systems Biology,Walter Reed Army Institute of Research,Silver Spring,MD 20910,USA||ORISE,Walter Reed Army Institute of Research,Silver Spring,MD 20910,USA
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Xiaomeng You,Melissa A.Kacena,Nabarun Chakraborty,Julia F.Charles,Jing Yan,Jeremy Herzog,Sabah Nobakhti,Ross Campbell,Allison Hoke,Rasha Hammamieh,R.Balfour Sartor,Sandra Shefelbine..Bone loss with aging is independent of gut microbiome in mice[J].骨研究（英文版）,2024,12(4):980-993,14.

基金项目

This work was supported by NIH grants R01 AG046257(JFC),the Orthopaedic Scholar Fund,the Department of Orthopaedic Surgery,Brigham and Women's Hospital,P30 AR075042 and the Joint Biology Consortium funded by P30-AR070253.Gnotobiotic studies were performed at National Gnotobiotic Rodent Resource Center at University of North Carolina at Chapel Hill,funded by P40-OD010995,P30-DK034987,and Crohn's and Colitis Foundation.This material is the result of work supported with resources and the use of facilities at the Richard L.Roudebush VA Medical Center,Indianapolis,IN:VA Merit#BX003751.The presented contents are solely the responsibility of the authors and do not necessarily represent the official views of any of the aforementioned agencies.We thank Dr.Antonios O.Aliprantis for helpful advice and technical assistance.We thank the Massachusetts Host-Microbiome Center for assistance with sequencing.Material has been reviewed by the Walter Reed Army Institute of Research.Research was conducted under an IACUC-approved animal use protocol in an AAALAC International-accredited facility with a Public Health Services Animal Welfare Assurance and in compliance with the Animal Welfare Act and other federal statutes and regulations relating to laboratory animals.There is no objection to its presentation and/or publication.The opinions or assertions contained herein are the private views of the author,and are not to be construed as official,or as reflecting true views of the Department of the Army or the Department of Defense. （JFC）

骨研究（英文版）

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ISSN：2095-4700

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