首页|期刊导航|骨研究（英文版）|KMT2A regulates the autophagy-GATA4 axis through METTL3-mediated m6A modification of ATG4a to promote NPCs senescence and IVDD progression

KMT2A regulates the autophagy-GATA4 axis through METTL3-mediated m6A modification of ATG4a to promote NPCs senescence and IVDD progression

Ouqiang Wu Kai Zhang Xiaofei Cheng Qizhu Chen Xinzhou Wang Yan Michael Li Zhenyu Guo Jing Sun Zhihua Chen Bin Wang Xiangyang Wang Yuxin Jin Shuying Shen Aimin Wu Zhiguang Zhang Hao Zhou Wenbin Xu Linjie Chen Morgan Jones Kenny Yat Hong Kwan Jianyuan Gao

骨研究（英文版）2024，Vol.12Issue(4)：1031-1048,18.

骨研究（英文版）2024，Vol.12Issue(4)：1031-1048,18.DOI:10.1038/s41413-024-00373-1

KMT2A regulates the autophagy-GATA4 axis through METTL3-mediated m6A modification of ATG4a to promote NPCs senescence and IVDD progression

Ouqiang Wu ¹Kai Zhang ²Xiaofei Cheng ²Qizhu Chen ¹Xinzhou Wang ¹Yan Michael Li ³Zhenyu Guo ¹Jing Sun ¹Zhihua Chen ¹Bin Wang ⁴Xiangyang Wang ¹Yuxin Jin ¹Shuying Shen ⁵Aimin Wu ¹Zhiguang Zhang ⁶Hao Zhou ⁷Wenbin Xu ⁵Linjie Chen ¹Morgan Jones ⁸Kenny Yat Hong Kwan ⁹Jianyuan Gao¹

作者信息

1. Department of Orthopaedics,Key Laboratory of Structural Malformations in Children of Zhejiang Province,Key Laboratory of Orthopaedics of Zhejiang Province,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,Zhejiang,China
2. Shanghai Key Laboratory of Orthopedic Implants,Department of Orthopedics,Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China
3. Department of Neurosurgery,University of Rochester Medical Center,Rochester,NY,USA
4. Department of Orthopaedic Surgery,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,China
5. Department of Orthopaedics,Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province,Sir Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou,China
6. Department of Emergency Medicine Center,Jinhua Municipal Central Hospital,Zhejiang,China
7. Department of Orthopaedics,Key Laboratory of Structural Malformations in Children of Zhejiang Province,Key Laboratory of Orthopaedics of Zhejiang Province,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,Zhejiang,China||Department of Orthopaedics,The First Affiliated Hospital of Ningbo University,Ningbo,Zhejiang,China
8. Spine Unit,The Royal Orthopaedic Hospital,Bristol Road South,Northfield,Birmingham,UK
9. Department of Orthopaedics and Traumatology,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Pokfulam,Hong Kong
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摘要

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Ouqiang Wu,Kai Zhang,Xiaofei Cheng,Qizhu Chen,Xinzhou Wang,Yan Michael Li,Zhenyu Guo,Jing Sun,Zhihua Chen,Bin Wang,Xiangyang Wang,Yuxin Jin,Shuying Shen,Aimin Wu,Zhiguang Zhang,Hao Zhou,Wenbin Xu,Linjie Chen,Morgan Jones,Kenny Yat Hong Kwan,Jianyuan Gao..KMT2A regulates the autophagy-GATA4 axis through METTL3-mediated m6A modification of ATG4a to promote NPCs senescence and IVDD progression[J].骨研究（英文版）,2024,12(4):1031-1048,18.

基金项目

The work was supported by the National Natural Science Foundation of China(82272555,82272522,82422044,82101647),Zhejiang Provincial Natural Science Foundation of China(LGF21H060010,LR22H060001,LY23H060011),Wenzhou Major Scientific and Technological Innovation Project(ZY2022010),Zhejiang Provincial Medical Technology Foundation of China(2022PY071). （82272555,82272522,82422044,82101647）

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