饮食运动联合干预对糖尿病前期人群干预效果的Meta分析OA北大核心

Objective:This systematic review aims to evaluate the effects of combined diet-exercise modifications on individu-als with prediabetes,aiming to provide compelling evidence for the prevention of prediabeteic conditions.Method:The search was conducted across multiple databases,including CNKI,VIP Database,Wanfang Database,the Cochrane Library,PubMed,Web of Science,and Embase.The search period encompassed the entire duration of the databases,starting from their inception and ex-tending until March 2024.Randomized controlled trials pertaining to prediabetes and combined diet-exercise were specifically cho-sen for inclusion.The included literature was subjected to a meta-analysis using Revman 5.4 software for statistical analysis.Re-sults:A total of 24 studies were included in the meta-analysis,which revealed that combined diet-exercise interventions significant-ly reduced the incidence of diabetes(RR=0.61,95%CI:0.51,0.72,P<0.001),fasting blood glucose(MD=-0.30,95%CI:-0.59,-0.01,P=0.04),glycated hemoglobin(MD=-0.25,95%CI:-0.40,-0.10,P<0.001),postprandial 2-hour blood glucose(MD=-0.78,95%CI:-1.41,-0.15,P=0.02),and BMI(MD=-0.69,95%CI:-1.16,-0.22,P=0.004),all demonstrating improvements as a result of these interventions.The subgroup analysis findings suggested that the intervention was more effective in individuals aged over 55 compared to those aged 55 or younger.However,further validation is required to con-firm the efficacy of longer-term interventions(>12 months).Conclusion:Combined diet-exercise interventions have been shown to effectively reduce the incidence of diabetes,fasting blood glucose levels,glycated hemoglobin levels,postprandial 2-hour blood glucose levels,and BMI among individuals in the prediabetic stage,thereby delaying the progression to diabetes.