海南医科大学学报2025，Vol.31Issue(1)：61-72,12.DOI:10.13210/j.cnki.jhmu.20240827.002
饮食运动联合干预对糖尿病前期人群干预效果的Meta分析
The effects of combined diet-exercise interventions on prediabetes:A systematic review and meta-analysis
摘要
Abstract
Objective:This systematic review aims to evaluate the effects of combined diet-exercise modifications on individu-als with prediabetes,aiming to provide compelling evidence for the prevention of prediabeteic conditions.Method:The search was conducted across multiple databases,including CNKI,VIP Database,Wanfang Database,the Cochrane Library,PubMed,Web of Science,and Embase.The search period encompassed the entire duration of the databases,starting from their inception and ex-tending until March 2024.Randomized controlled trials pertaining to prediabetes and combined diet-exercise were specifically cho-sen for inclusion.The included literature was subjected to a meta-analysis using Revman 5.4 software for statistical analysis.Re-sults:A total of 24 studies were included in the meta-analysis,which revealed that combined diet-exercise interventions significant-ly reduced the incidence of diabetes(RR=0.61,95%CI:0.51,0.72,P<0.001),fasting blood glucose(MD=-0.30,95%CI:-0.59,-0.01,P=0.04),glycated hemoglobin(MD=-0.25,95%CI:-0.40,-0.10,P<0.001),postprandial 2-hour blood glucose(MD=-0.78,95%CI:-1.41,-0.15,P=0.02),and BMI(MD=-0.69,95%CI:-1.16,-0.22,P=0.004),all demonstrating improvements as a result of these interventions.The subgroup analysis findings suggested that the intervention was more effective in individuals aged over 55 compared to those aged 55 or younger.However,further validation is required to con-firm the efficacy of longer-term interventions(>12 months).Conclusion:Combined diet-exercise interventions have been shown to effectively reduce the incidence of diabetes,fasting blood glucose levels,glycated hemoglobin levels,postprandial 2-hour blood glucose levels,and BMI among individuals in the prediabetic stage,thereby delaying the progression to diabetes.关键词
生活方式/饮食运动/糖尿病前期/Meta分析Key words
Lifestyle/Diet and exercise/Prediabetes/Meta-analysis分类
临床医学引用本文复制引用
郑传雷,曾少波,吴清锋..饮食运动联合干预对糖尿病前期人群干预效果的Meta分析[J].海南医科大学学报,2025,31(1):61-72,12.基金项目
National Natural Science Foundation of China(81960621)国家自然科学基金资助项目(81960621) （81960621）
