海南医科大学学报2025，Vol.31Issue(1)：73-80,8.DOI:10.13210/j.cnki.jhmu.20240830.003
Klotho靶向钙库操纵性钙内流调控上皮-间充质转化治疗纤维化疾病的研究进展
Research progress on targeting klotho-mediated store-operated calcium entry regulation of epithelial-mesenchymal transition for the treatment of fibrotic diseases
摘要
Abstract
The development of fibrotic diseases is often attributed to a recurrent cycle of chronic inflammation,injury,and re-pair.Growing evidence suggests that tissue injury can promote fibrosis progression by activating epithelial to mesenchymal transi-tion(EMT),which involves fibroblast activation,cell migration and invasion,as well as excessive accumulation of extracellular matrix.Recent studies have shown that store-operated calcium entry(SOCE)promotes EMT and worsens fibrotic diseases,while inhibiting its signaling can help prevent and control fibrosis.In this context,the anti-aging protein Klotho may play a regulatory role in preventing and controlling fibrotic diseases by regulating SOCE.Therefore,this paper aims to review recent studies on the role of SOCE in regulating EMT in fibrotic diseases,as well as the potential regulatory function of Klotho,in order to offer theo-retical support for future research.关键词
Klotho/纤维化/钙库操纵性钙内流/上皮-间充质转化Key words
Klotho/Fibrosis/Store-operated calcium entry/Epithelial to mesenchymal transition分类
基础医学引用本文复制引用
刘禹杉,杨树森,张仪霖,李京涛,闫曙光..Klotho靶向钙库操纵性钙内流调控上皮-间充质转化治疗纤维化疾病的研究进展[J].海南医科大学学报,2025,31(1):73-80,8.基金项目
This study was supported by National Natural Science Foundation of China(81873233,82174330) （81873233,82174330）
Shaanxi University of Traditional Chinese Medicine Science and Technology Innovation Team(2023-CXTD-01)国家自然科学基金资助项目(81873233、82174330) （2023-CXTD-01）
陕西中医药大学科技创新团队(2023-CXTD-01) （2023-CXTD-01）
