合成材料老化与应用2024，Vol.53Issue(6)：20-23,4.
TPU/HM-531改性材料制备及生物相容性评价
Preparation and Biocompatibility Evaluation of TPU/HM-531 Blends
摘要
Abstract
TPU/HM-531 hydrophilic modified blends were prepared by melt blending with HM-531 as a hydrophilic modifier for TPU.The hydrophilicity and cytotoxicity of the blends were investigated.As the content of HM-531 content increases,the contact angle of the blends gradually decreases.They are 37.89° and 26.59° respectively for blend with 2.5％and 7.5％content of HM-531,indicating a good hydrophilic modification effect.The blends with HM-531 content ranging from 2.5％to 7.5％showed no cytotoxicity with a relative cell growth rate of ≥90％after 1 day,3 days,and 5 days of cultivation.When the extraction solution of the experimental blend group was diluted 50 times,most of the cells were observed to be spindle shaped and in good growth state under the microscope.The fluorescence detection of live/dead cells showed that the majority of cells showed green color and only a few cells showed red color,which shows no significant difference compared to the negative control.Blends with excellent hydrophilicity and good biocompatibility can be prepared by adding 2.5％～7.5％HM-531 to TPU.关键词
热塑性聚氨酯(TPU)/聚氧化乙烯-氧化丙烯共聚物/亲水改性/接触角/生物相容性Key words
thermoplastic polyurethane(TPU)/ethylene oxide-propylene oxide copolymer/hydrophilic modification/contact angle/biocompatibility分类
化学化工引用本文复制引用
林泽铨,李荣荣,阳范文,王庆琳,陈晓邦,欧阳阅翰,田慧,赵晨,利希婷,余子卉,朱锐钿..TPU/HM-531改性材料制备及生物相容性评价[J].合成材料老化与应用,2024,53(6):20-23,4.基金项目
广东省药监局科技项目(2023YDZ12) （2023YDZ12）
广东省普通高校质量工程项目(2023年度医疗器械现代产业学院) （2023年度医疗器械现代产业学院）
广州医科大学学生创新能力提升计划项目(2023-50) （2023-50）
广州医科大学2023年度质量工程项目(2023ZLGC129). （2023ZLGC129）
