基础医学与临床2025，Vol.45Issue(2)：148-153,6.DOI:10.16352/j.issn.1001-6325.2025.02.0148
骨关节炎与心血管疾病交互影响的研究进展
Research progress on the interaction between osteoarthritis and cardiovascular diseases
摘要
Abstract
Osteoarthritis(OA)is closely related to cardiovascular disease(CVD).The incidence of CVD is signifi-cantly higher in the population of OA patients.This review first analyzes the epidemiology and common risk factors of OA and CVD,then discusses the pathogenesis of OA and CVD,and clarifies the roles of chronic low-grade in-flammation,metabolic syndrome,endothelial dysfunction,as well as macrophages,T⁃cells,and inflammatory fac⁃tors involved in the mechanisms of interaction between OA and CVD.The review further analyzes treatment strate⁃gies and preventive measures for OA and CVD,explores the impact of OA treatment drugs on cardiovascular safety,and elucidates the importance of cardiovascular risk assessment and management in OA patients for clinical diagno⁃sis and treatment.Finally,this review orientes future research directions of OA and CVD,including in⁃depth explo⁃ration of the molecular and cellular mechanisms between OA and CVD,drug interactions,and the development of new treatment strategies,aiming to provide ideas for improving the clinical diagnosis,treatment and prognosis of OA and CVD.关键词
骨关节炎/心血管疾病/机制/治疗/预防Key words
osteoarthritis/cardiovascular disease/mechanism/treatment/prevention分类
医药卫生引用本文复制引用
杨剑锋,郝琳,王岩,冀全博..骨关节炎与心血管疾病交互影响的研究进展[J].基础医学与临床,2025,45(2):148-153,6.基金项目
国家自然科学基金(82272558) （82272558）
