激光生物学报2024，Vol.33Issue(6)：512-522,11.DOI:10.3969/j.issn.1007-7146.2024.06.005
HIF-1α/PFKFB3信号通路介导GK调节2型糖尿病胰岛β细胞功能的研究进展
HIF-1α/PFKFB3 Signaling Pathway Mediates GK Regulation of Islets in Type 2 Diabetes β Progress in Cellular Function Research
摘要
Abstract
Islet β cells are the exclusive cellular source of insulin synthesis and secretion,playing a crucial role in regulating blood glucose homeostasis.The impairment of islet β cells due to sustained anaerobic glycolysis pressure represents a significant factor contributing to insulin deficiency or resistance in patients with type 2 diabetes mellitus(T2DM).Glucokinase(GK),serving as the principal rate-limiting step in glucose transport,exhibits close association with insulin secretion.Hypoxia-inducible factor 1α subunit(HIF-1α)and 6-phosphofructo-2-kinase(PFKFB3)act as pivotal regulatory factors within glycolysis.The HIF-1α/PFKFB3 signaling pathway participates in intricate pathophysiological processes involving islet β cell function and maintenance under high-glucose conditions.This review elucidates the mechanisms by which the HIF-1α/PFKFB3 signaling pathway mediates GK induction through anaerobic glycolysis,mitochondrial network adaptive fragmentation,oxidative stress,and dedifferentiation leading to pancreatic islet β cell dysfunction in T2DM,thereby offering novel insights for clinical prevention and treatment strategies targeting T2DM.关键词
2型糖尿病/葡萄糖激酶/HIF-1α/PFKFB3信号通路/线粒体/去分化Key words
type 2 diabetes/glucokinase/HIF-1α/PFKFB3 signaling pathway/mitochondria/dedifferentiation分类
医药卫生引用本文复制引用
魏皓月,张茜,魏代浩,李欢,王瑞,黄延芹..HIF-1α/PFKFB3信号通路介导GK调节2型糖尿病胰岛β细胞功能的研究进展[J].激光生物学报,2024,33(6):512-522,11.基金项目
国家自然科学基金项目(81974562) （81974562）
山东省泰山学者工程专项项目(tsqn202211354) （tsqn202211354）
山东省自然科学基金项目(ZR2024MH245) （ZR2024MH245）
钱秋海全国名老中医药专家传承工作室建设项目(国中医药人教函[2022]75号). （国中医药人教函[2022]75号）
