激光生物学报2024，Vol.33Issue(6)：541-549,9.DOI:10.3969/j.issn.1007-7146.2024.06.008
RETN基因与骨密度及骨折的因果关系研究
A Study on the Casual Relationship Between RETN Gene and BMD and Fracture
罗海勇 1庞伟伟 2卢璇 2杨俊骁 3谭丽君2
作者信息
- 1. 湖南交通工程学院,衡阳 421000||湖南中医药大学湘杏学院,湘阴 410007
- 2. 湖南师范大学生命科学学院,长沙 410081
- 3. 中南大学湘雅医院骨外科,长沙 410008
- 折叠
摘要
Abstract
Osteoporosis is the most common systemic and metabolic bone disease.The concentration of serum resistin(RETN)is associated with bone mineral density,but it is still unclear whether there is a causal relationship between RETN and bone density and fractures.This study used Mendelian randomization(MR)to analyze the causal relationship between RETN gene expression and bone mineral density and fractures,and then analyzed the differential expression of RETN gene in single-cell sequencing data of femeral neck fracture(FNF)and osteoarthritis(OA)samples.MR analysis showed that high expression of RETN was found to lead to decreased bone mineral density and increased risk of fractures.RETN expression was upregulated in the FNF group,and RETN was mainly expressed by neutrophils.The inflammatory chemokine CXCL8 related to RETN was significantly upregulated in the FNF group.This study suggested the role of RETN in the pathogenesis of osteoporosis,providing a basis for the diagnosis and treatment of osteoporosis.关键词
骨质疏松症/抵抗素/孟德尔随机化分析/单细胞RNA测序/骨密度Key words
osteoporosis/RETN/Mendelian randomization/single-cell RNA sequencing/bone mineral density分类
医药卫生引用本文复制引用
罗海勇,庞伟伟,卢璇,杨俊骁,谭丽君..RETN基因与骨密度及骨折的因果关系研究[J].激光生物学报,2024,33(6):541-549,9.
