昆明医科大学学报2025，Vol.46Issue(2)：37-43,7.DOI:10.12259/j.issn.2095-610X.S20250206
1800MHz电磁辐射对3xTg-AD和C57小鼠的学习及认知功能影响
The Effect of 1 800 MHz Electromagnetic Radiation on Learning and Cognitive Functions in 3xTg-AD Mice
摘要
Abstract
Objective To explore the effects of 1 800 MHz electromagnetic radiation(EMR)on cognitive function of 3xTg-AD and 57C mice,providing a theoretical basis for the potential impacts of electromagnetic radiation on the human body.Methods A total of 12 3xTg-AD transgenic mice and 12 wild-type C57 mice were selected as research subjects.The one-month-old mice were divided into four groups:RF WT,Control WT,RF AD,and Control AD,with 6 mice in each group.The 1 800 MHz EMR exposure experiments were conducted from 20:00 to 8:00 the next day for a duration of 5 months.After the exposure,a water maze test was conducted to evaluate the effects of EMR on spatial learning and memory abilities of 3xTg AD mice,along with measurements of body weight,brain weight,and calculation of the brain-to-body ratio.Finally,Western Blot technique was used to measure the levels of APP,NR1,and NR2A in hippocampal tissue to analyze effects of 1 800 MHz EMR on the cognitive function of 3xTg AD mice.Results Under 1 800 MHz EMR exposure,there were no statistically significant differences in Morris water maze spatial learning ability among the four groups(P>0.05).However,longer escape time,greater swimming distances,and more crossings of target quadrant were exhibited in the RF AD group compared to the other groups(P<0.05).Western Blot results showed that the APP protein levels in 3xTg AD mice was higher than those in C57 mice(P<0.05).The expression levels of NR1 protein in the WT group was higher than those in the AD group(P<0.05);in the AD group,the RF AD group had higher levels than the Control WT group(P<0.05),and the NR2A protein levels in the Control WT group were higher than in the other groups(P<0.05).Conclusion Prolonged exposure to 1 800 MHz EMR can affect the learning and cognitive function of both 3xTg AD and C57 mice.关键词
电磁辐射/3xTg-AD小鼠/淀粉样前体蛋白/N-甲基-D-天冬氨酸受体1/N-甲基-D-天冬氨酸受体2AKey words
Electromagnetic radiation/3xTg-AD mice/Amyloid precursor protein/N-methyl-D-aspartate receptor 1/N-methyl-D-aspartate receptor 2A分类
临床医学引用本文复制引用
徐晓霜,马国玉,和润华,赵永丽,武慧欣,木云珍..1800MHz电磁辐射对3xTg-AD和C57小鼠的学习及认知功能影响[J].昆明医科大学学报,2025,46(2):37-43,7.基金项目
云南省科技厅-昆明医科大学应用基础研究联合专项基金(202101AY070001-056 （）
202101AY070001-057) （）
