昆明医科大学学报2025，Vol.46Issue(2)：44-50,7.DOI:10.12259/j.issn.2095-610X.S20250207
miR-146a基因多态性与宫颈上皮内瘤变的相关性
The Association between miR-146a Gene Polymorphism and Cervical Intraepithelial Neoplasia
摘要
Abstract
Objective To investigate the association between single nucleotide polymorphisms(SNP)rs57095329 and rs6864584 of miR-146a gene and cervical intraepithelial neoplasia(CIN).Methods A total of 96 patients diagnosed with CIN were randomly collected as the CIN group,and 225 healthy individuals examined during the same period were selected as the control group using SPSS software.Genotyping of the above SNP loci was performed using the TaqMan probe method,and their correlation with CIN was analyzed.Results The allele and genotype distribution of rs57095329 showed a statistically significant differences compared to the control group,with the frequency of the allele A in the CIN group significantly lower than that in the control group(P<0.001;OR=0.48,95%CI:0.32～0.70).In the dominant model,individuals carrying the G allele(A/G-G/G)had a significantly increased risk of CIN(P<0.001;OR=2.67,95%CI:1.64～4.37).In contrast,no correlation was found between the rs6864584 and the risk of CIN.Conclusion The A allele of the miR-146a gene at the rs57095329 locus may be a protective factor for CIN.关键词
MicroRNAs/宫颈上皮内瘤变/单核苷酸多态性Key words
MicroRNAs/Cervical intraepithelial neoplasia/Single nucleotide polymorphisms分类
临床医学引用本文复制引用
师雨晗,柴江红,许金美,林牧,姚宇峰,何凤权,严志凌..miR-146a基因多态性与宫颈上皮内瘤变的相关性[J].昆明医科大学学报,2025,46(2):44-50,7.基金项目
云南省基础研究计划基金(202201AY070001-139) （202201AY070001-139）
保山市科技计划项目-2023年医学研究联合专项基金(2023bskjylms016) （2023bskjylms016）
