昆明医科大学学报2025，Vol.46Issue(2)：74-79,6.DOI:10.12259/j.issn.2095-610X.S20250211
术前空腹甘油三酯-血糖指数对颈内动脉支架置入术后对侧新发无症状缺血性脑损伤的预测价值
Preoperative Fasting Triglyceride-glucose Index as a Predictor of Contralateral New Silent Ischemic Brain Lesions after Carotid Artery Stenting
摘要
Abstract
Objective To investigate the predictive value of the preoperative fasting Triglyceride-Glucose index(TyG)for contralateral new silence ischemic brain lesions(CNSIBL)following carotid artery stenting(CAS).Methods A retrospective study was conducted to analyze the clinical data of 183 patients who underwent carotid CAS.The patients were divided into a CNSIBL group(50 cases)and a non-CNSIBL group(133 cases)based on the occurrence of CNSIBL.Baseline data,laboratory tests,and imaging indicators were collected,and TyG was calculated.Using the occurrence of CNSIBL as the dependent variable,multivariate logistic regression analysis was performed with TyG as the independent variable after controlling for confounding factors,and the predictive value of TyG for CNSIBL post-CAS was evaluated using receiver operating characteristic(ROC)curves.Results(1)The number of patients with a history of diabetes mellitus,as well as systolic and diastolic blood pressure on admission in CNSIBL group were statistically significantly higher than that in non-CNSIBL group(P<0.05).(2)Triglyceride(TC)levels were higher in the CNSIBL group compared to the non-CNSIBL group(P<0.05);TyG was also higher in the CNSIBL group than in the non-CNSIBL group(P<0.05);(3)Multivariate Logistic regression analysis results showed that TyG[a OR=1.125,95%CI(1.042-1.214),P<0.001]was an independent risk factor for contralateral new silent ischemic brain lesions after carotid artery stenting;(4)The ROC curve suggested that the AUC for TyG predicting contralateral new silent ischemic brain lesions post-CAS was 0.77[95%CI(0.71-0.84),P<0.001],with a cut-off value of 1.93,sensitivity of 86.0%,and specificity of 63.9%.Conclusion TyG is an independent influencing factor for contralateral new silent ischemic brain lesions following carotid artery stenting.关键词
颈内动脉支架置入术/对侧新发无症状缺血性脑损伤/甘油三酯-血糖指数/动脉粥样硬化Key words
Carotid artery stenting/Contralateral new silence ischemic brain lesions/Triglyceride-glucose index/Atherosclerosis分类
医药卫生引用本文复制引用
杨毅,申珅,万孟夏,张拥波..术前空腹甘油三酯-血糖指数对颈内动脉支架置入术后对侧新发无症状缺血性脑损伤的预测价值[J].昆明医科大学学报,2025,46(2):74-79,6.基金项目
国家自然科学基金面上项目(81671191) （81671191）
