昆明医科大学学报2025，Vol.46Issue(2)：158-163,6.DOI:10.12259/j.issn.2095-610X.S20250222
恶性黑色素瘤靶向治疗及其耐药机制研究进展
Research Progress on Targeted Therapy and Resistance Mechanisms of Malignant Melanoma
摘要
Abstract
Malignant melanoma is an extremely aggressive tumor that can be surgically treated in its early stage.In advanced stages,the invasive and proliferative capabilities of melanoma cells continue to increase,and traditional treatment methods such as radiotherapy,chemotherapy,and immunotherapy have limited efficacy,resulting in poor patient prognosis.Due to the presence of mutations in multiple molecular pathways in malignant melanoma,targeted therapy is now regarded as a more viable treatment option for patients with advanced malignant melanoma,with most patients benefiting from it.However,the development of drug resistance to targeted therapy has always been a serious challenge,as the emergence of resistance limits the efficacy.Therefore,it is necessary to explore the mechanism and drug resistance of targeted therapy of malignant melanoma.关键词
恶性黑色素瘤/靶向治疗/耐药机制Key words
Malignant melanoma/Targeted therapy/Drug resistance mechanisms分类
医药卫生引用本文复制引用
刘一帆,罗星,宋天慈,杨志惠..恶性黑色素瘤靶向治疗及其耐药机制研究进展[J].昆明医科大学学报,2025,46(2):158-163,6.基金项目
国家自然科学基金(82273395) （82273395）
