临床小儿外科杂志2025，Vol.24Issue(1)：39-44,6.DOI:10.3760/cma.j.cn101785-202207032-008
最大尿流率变化在男童生殖器硬化性苔藓样变治疗中的临床意义
Significance of changes in maximum urinary flow rate in boys with genital lichen sclerosus
摘要
Abstract
Objective To summarize the clinical data with genital lichen sclerosus(GLS)and explore the significance of maximum urinary flow rate in its diagnosis and management.Methods This retrospective study analyzed clinical data from 41 boys diagnosed with GLS and treated surgically at the Department of Urology,Chengdu Women's and Children's Central Hospital between April 2020 and June 2021.Patients were grouped by urinary difficulty(urinary difficulty group,n=16;no urinary difficulty group,n=25),preoperative corticosteroid use(preoperative corticosteroid group,n=11;no preoperative corticosteroid group,n=30),postoperative cortico-steroid use(postoperative corticosteroid group,n=6;no postoperative corticosteroid group,n=35),and urethral meatus involvement(involvement group,n=4;no involvement group,n=37).Preoperative and postoperative maximum urinary flow rates were recorded and compared among groups.Results A total of 41 cases met patho-logical diagnostic criteria.Maximum urinary flow rate significantly improved from preoperative(10.88±4.26)mL/s to 1 month(14.44±4.02)mL/s,3 months(16.84±2.69)mL/s,6 months(18.28±3.76)mL/s,and 12 months(17.60±2.57)mL/s postoperatively(P＜0.05).Preoperatively,21 patients had abnormal maximum urinary flow rate,which decreased to 6 cases at 1 month postoperatively and resolved completely at 3,6,and 12 months.The preoperative corticosteroid group showed no significant difference in normalized maximum urinary flow rates at 1 month postoperatively compared to the non-corticosteroid group[63.6％(7/11)vs.93.1％(27/29),x2=3.366,P＞0.05].The postoperative corticosteroid group had significantly fewer cases of normalized maximum urinary flow rates at 1 month compared to the non-corticosteroid group[16.7％(1/6)vs.97.1％(33/34),x2=19.931,P＜0.05].Similarly,the urethral meatus involvement group showed fewer normalized maximum urinary flow rate cases at 1 month postoperatively compared to the non-involvement group[0.0％(0/4)vs.94.4％(34/36),P＜0.05].Conclusions Surgical treatment improves postoperative maximum urine flow rate in boys with GLS.Preoperative use of corticosteroid ointments may not improve postoperative maximum urinary flow rate but can serve as an adjunct therapy for patients with abnormal maximum urinary flow rates.Maximum urinary flow rate can be considered an important reference indicator for assessing voiding function in children with GLS.关键词
硬化性苔藓样变/尿流率/外科手术/儿童Key words
Lichen Sclerosus/Urinary Flow Rate/Surgical Procedures,Operative/Child引用本文复制引用
赵兴,邓常开,彭强,陈月娇,朱俊杰,张昊东,张炜..最大尿流率变化在男童生殖器硬化性苔藓样变治疗中的临床意义[J].临床小儿外科杂志,2025,24(1):39-44,6.基金项目
成都市医学科研项目(2019017) Chengdu Medical Research Project(2019017) （2019017）
