针刺联合穴位贴敷对非小细胞肺癌相关性便秘患者生活质量的影响OA

Objective To observe the effect of Shang Xia Tong Tiao acupuncture plus application at Shenque(CV8)on stool form,intestinal flora,and quality of life in patients with non-small-cell lung cancer(NSCLC)-associated constipation.Method A total of 108 patients with NSCLC-associated constipation were recruited and allocated to a control group,an abdominal acupuncture group,and an observation group using the random number table method,with 36 participants in each group.Health guidance was offered to all three groups.In addition,the control group received application at Shenque.In addition to the intervention given to the control group,the acupuncture group received acupuncture treatment,and the observation group received Shang Xia Tong Tiao acupuncture treatment.The Wexner continence grading scale(WCGS)score and Bristol stool form score were observed before the treatment and after 1,2,and 3 weeks of treatment.The three groups were also observed for post-treatment changes in the patient-assessment of constipation quality of life(PAC-QOL)score,serum levels of 5-hydroxytryptamine(5-HT)and vasoactive intestinal peptide(VIP),and intestinal flora levels(Roseobacter,Bifidobacterium,and Erysipelothrix).Result The treatment method and timing had interaction effects on the WCGS and Bristol scores(P＜0.05);the WCGS score was lower in the observation group compared to the other two groups after 2 and 3 weeks of treatment,respectively(P＜0.05),and the Bristol score was lower in the observation group than in the other two groups after 1,2,and 3 weeks of treatment(P＜0.05).After the treatment,three dimension scores in the PAC-QOL,i.e.physical discomfort,worry and anxiety,and satisfaction degree,were lower in the observation group than in the other two groups(P＜0.05).After the intervention,the observation group had a higher serum 5-HT level and Bifidobacterium relative abundance compared to the other two groups(P＜0.05),the serum VIP level and the relative abundance of Erysipelothrix were lower in the observation group than in the other two groups(P＜0.05),and the observation group had a higher relative abundance of Roseobacter than the control group(P＜0.05).Conclusion With health guidance,Shang Xia Tong Tiao acupuncture plus application at Shenque can improve constipation symptoms,stool form,and brain-gut peptide indicators and regulate intestinal floral disorders in patients with NSCLC-associated constipation.