头穴埋线联合中药治疗阿尔兹海默病的疗效观察及对可溶性凋亡因子的影响OA

Objective To observe the clinical efficacy of catgut-embedding therapy at scalp acupoints combined with Yi Shen Yi Zhi decoction in the treatment of Alzheimer disease of kidney essence deficiency pattern and its effect on serum soluble apoptosis-related factor(sFas),amyloproposition β resolvase 1(BACE1),monocyte chemoattractant protein-1(MCP-1)and malondi-aldehyde(MDA).Method A total of 136 patients with Alzheimer disease of kidney essence deficiency pattern were selected as the study objects and divided into a control group(68 patients)and an observation group(68 patients)according to the random number table method.The control group was treated with conventional Western medicine,while the observation group was treated with catgut-embedding therapy at scalp acupoints combined with Yi Shen Yi Zhi decoction in addition to the treatment in the control group.Before and after the treatment,the traditional Chinese medicine(TCM)pattern score,Alzheimer disease assessment scale-cog(ADAS-cog)score,mini-mental state examination(MMSE)score,and serum sFas,BACE1,MCP-1,MDA,brain-derived neurotrophic factor(BDNF),noradrenaline(NE)and vascular endothelial growth factor(VEGF)levels were observed in the two groups,and the clinical efficacy and occurrence of adverse reactions between the two groups were compared.Result The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P＜0.05).After the treatment,the TCM pattern scores,ADAS-cog scores and MMSE scores of both groups improved compared with those before treatment(P＜0.05),and the above scores of the observation group were better than those of the control group(P＜0.05).After treatment,the serum sFas,BACE1 and MDA levels of the observation group were lower than those of the control group(P＜0.05),and the serum BDNF,NE and VEGF levels were higher than those of the control group(P＜0.05).There was no statistically significant difference in serum MCP-1 levels between the two groups after treatment(P＞0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion On the basis of conventional treatment in Western medicine,the combination of catgut-embedding therapy at scalp acupoints and Yi Shen Yi Zhi decoction in the treatment of Alzheimer disease of kidney essence deficiency pattern can improve the clinical efficacy,help to reduce the inflammatory response,and further improve the imbalance of oxidative stress and cognitive level.