针刺治疗阈下抑郁的临床观察及对血清IL-6、IL-1β和TNF-α水平的影响OA

Objective To observe the clinical efficacy of Shu Gan Tiao Shen acupuncture for subthreshold depression and its effect on serum interleukin-6(IL-6),interleukin-1β(IL-1β)and tumor necrosis factor-α(TNF-α)levels in the patients.Method Sixty-two patients with subthreshold depression were randomized to a treatment group and a control group,with 31 cases in each group.In the treatment group,one case dropped out during treatment and finally 30 cases were included.The treatment group received Shu Gan Tiao Shen acupuncture and the control group received sham acupuncture.The clinical therapeutic effects were compared between the two groups.The center for epidemiologic studies depression scale(CES-D),the Hamilton depression scale(HAMD)and the MOS 36-item short form health survey(SF-36)scores were recorded in the two groups before and after treatment.Serum IL-6,IL-1β and TNF-α contents were measured in the two groups before and after treatment.Result After treatment,the CES-D and HAMD scores decreased and the SF-36 score increased in the two groups(P＜0.05)and they were better in the treatment group than in the control group(P＜0.05).After treatment,serum IL-6,IL-1β and TNF-α contents decreased in the treatment group(P＜0.05)and had no statistically significant difference in the control group compared with before(P＞0.05).Conclusion Shu Gan Tiao Shen acupuncture can effectively relieve the depressive state and improve the quality of life in treating patients with subthreshold depression.It may be related to reducing the immunologic reaction to inflammation in the patients.