无痛化脓灸治疗痰浊阻滞型老年高脂血症的疗效观察OA
Therapeutic observation of painless suppurative moxibustion in treating hyperlipidemia due to phlegm turbidity obstruction in older people
目的 观察无痛化脓灸治疗痰浊阻滞型老年高脂血症的临床疗效及对血清载脂蛋白A1(apolipoprotein A1,ApoA1)、载脂蛋白 B(apolipoprotein B,ApoB)、ApoB/ApoA1 比值和同型半胱氨酸(homocysteine,Hcy)水平的影响.方法 将90 例痰浊阻滞型老年高脂血症患者随机分为观察组和对照组,每组45 例.对照组用瑞舒伐他汀钙片治疗,观察组在对照组基础上联合改良无痛麦粒化脓灸治疗.观察两组治疗前后中医证候积分、血脂[总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)和高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)]水平、血清载脂蛋白(ApoA1、ApoB和ApoB/ApoA1)水平和Hcy水平的变化情况,比较两组临床疗效.结果 治疗后,两组中医证候积分、血脂(TC、TG和LDL-C)水平、血清载脂蛋白(ApoB、ApoB/ApoA1)和Hcy水平均较同组治疗前下降(P＜0.05),观察组HDL-C和ApoA1水平较同组治疗前升高(P＜0.05).观察组治疗后中医证候积分、TC、TG、LDL-C、ApoB、ApoB/ApoA1及Hcy水平均低于对照组(P＜0.05).观察组总有效率为 95.3%,高于对照组的 81.4%,差异具有统计学意义(P＜0.05).治疗过程中,两组患者均无明显不适,且安全性指标无异常.结论 在口服瑞舒伐他汀钙片治疗基础上,无痛化脓灸治疗痰浊阻滞型老年高脂血症能进一步调节各项血脂、血清载脂蛋白及Hcy水平,提高临床疗效,且安全性较好.
Objective To observe the clinical efficacy of painless suppurative moxibustion in treating hyperlipidemia due to phlegm turbidity obstruction in older people and its effects on serum levels of apolipoprotein A1(ApoA1),apolipoprotein B(ApoB),ApoB/ApoA1,and homocysteine(Hcy).Method Ninety aged participants with hyperlipidemia due to phlegm turbidity obstruction were randomized into an observation group and a control group,each consisting of 45 cases.The control group was treated with Rosuvastatin calcium tablets;in addition to that,the observation group was offered the modified painless suppurative moxibustion.The traditional Chinese medicine(TCM)pattern score,blood lipid levels[total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),and high-density lipoprotein cholesterol(HDL-C)],and serum levels of apolipoproteins(ApoA1,ApoB,and ApoB/ApoA1)and Hcy were observed before and after the treatment in both groups.The clinical efficacy was compared between the two groups.Result After the treatment,the TCM pattern score,blood lipid(TC,TG,and LDL-C)levels,and serum levels of apolipoproteins(ApoB and ApoB/ApoA1)and Hcy dropped in both groups(P＜0.05),and the observation group had an increase in the levels of HDL-C and ApoA1(P＜0.05).After the intervention,the observation group was lower than the control group in comparing the TCM pattern score and the levels of TC,TG,LDL-C,ApoB,ApoB/ApoA1,and Hcy(P＜0.05).The total effective rate was 95.3%in the observation group,higher than 81.4%in the control group,and the difference was statistically significant(P＜0.05).During the treatment process,no participants experienced significant discomfort,and their safety indicators were all within the normal range.Conclusion Integrating painless suppurative moxibustion into oral administration of Rosuvastatin calcium tablets can better regulate blood lipid and serum apolipoprotein and Hcy levels,and enhance clinical efficacy with a satisfactory safety rating in treating hyperlipidemia due to phlegm turbidity obstruction in older patients.
何梦佳;郭金依;王君宜;陈国华;苏秀贞
山东第二医科大学,潍坊 261053山东第二医科大学,潍坊 261053承德医学院,承德 067000潍坊市人民医院,潍坊 261041潍坊市中医院,潍坊 261041
中医学
灸法艾炷灸高脂血症痰浊阻滞老年人
MoxibustionMoxa cone moxibustionHyperlipidemiaPhlegm turbidity obstructionAged
《上海针灸杂志》 2025 (2)
202-207,6
山东省中医药管理局齐鲁医派中医药特色技术推广项目[鲁卫函(2020)132号]山东省保健科技协会科学技术项目(SDBJKT20180101)
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