上海针灸杂志2025，Vol.44Issue(2)：219-224,6.DOI:10.13460/j.issn.1005-0957.2025.02.0219
针刺治疗带状疱疹后遗神经痛的疗效观察及对机体免疫和血管生成的影响
Observation on the efficacy of acupuncture for postherpetic neuralgia and its effect on bodily immunity and angiogenesis
摘要
Abstract
Objective To observe the clinical efficacy of acupuncture for postherpetic neuralgia and its effect on bodily immunity and angiogenesis.Method The included ninety-eight patients with postherpetic neuralgia were allocated,using a random number table,to a basic group and an acupuncture group,with 49 cases in each group.The basic group received conventional Western medical treatment and the acupuncture group received acupuncture in addition.The clinical therapeutic effects were compared between the two groups.The TCM syndrome score,the present pain intensity(PPI)score,the pain visual analog scale(VAS)score,the Beck anxiety intensity(BAI)score and the dermatology life quality index(DLQI)score were recorded in the two groups before and after treatment.Nerve injury-induced protein 1(NINJ1),interleukin-1β(IL-1β),C-C motif chemokine ligand 2(CCL2),β-endorphin(β-EP),vascular endothelial growth factor(VEGF),calcitonin gene-related peptide(CGRP),T lymphocyte subsets CD4+and CD8+,and complement C3 levels in serum were measured in the two groups before and after treatment.Result The total efficacy rate was 95.9%in the acupuncture group,which was higher than 79.6%in the basic group with a statistically significant difference(P＜0.05).After treatment,the TCM syndrome item scores all decreased in the two groups compared with before(P＜0.05)and the TCM syndrome score was lower in the acupuncture group than in the basic group(P＜0.05).After treatment,the VAS,PPI,BAI and DLQI scores all decreased in the two groups compared with before(P＜0.05)and were lower in the acupuncture group than in the basic group(P＜0.05).After treatment,NINJ1,IL-1β,CCL2,VEGF,CGRP and CD8+levels all decreased in the two groups compared with before(P＜0.05)and were lower in the acupuncture group than in the basic group(P＜0.05).After treatment,β-EP,CD4+and complement C3 levels all increased in the two groups compared with before(P＜0.05)and were higher in the acupuncture group than in the basic group(P＜0.05).Conclusion On the basis of conventional Western medical treatment,acupuncture can further relieve the pain and improve the quality of life and the clinical therapeutic effect in treating postherpetic neuralgia.It may be related to modulating CCL2 levels,promoting nerve repair,inhibiting inflammation and improving immunity and vascular endothelial growth factor levels.关键词
针刺疗法/针药并用/神经痛,带状疱疹后/镇痛/炎症Key words
Acupuncture therapy/Acupuncture medication combined/Neuralgia,Postherpetic/Analgesia/Inflammation分类
医药卫生引用本文复制引用
杨树,刘璇,张冀..针刺治疗带状疱疹后遗神经痛的疗效观察及对机体免疫和血管生成的影响[J].上海针灸杂志,2025,44(2):219-224,6.基金项目
盐城市科技局重点研发计划项目(YCBE202229) （YCBE202229）
