外科理论与实践2024，Vol.29Issue(5)：405-408,4.DOI:10.16139/j.1007-9610.2024.05.07
《双磷酸盐和其他骨调节剂在乳腺癌辅助治疗中的应用:ASCO-OH(CCO)指南更新》解读
The interpretation of Use of Adjuvant Bisphosphonates and Other Bone-Modifying Agents in Breast Cancer:ASCO-OH(CCO)Guideline Update
摘要
Abstract
Bone-modifying agents(BMAs),including bisphosphonate(BP)and denosumab,can reduce bone-related events caused by breast cancer bone metastasis."Use of Adjuvant Bisphosphonates and Other Bone-Modifying Agents in Breast Cancer:ASCO-OH(CCO)Guideline Update"was published in Journal of Clinical Oncology in January 2022.The new"2022 version Guideline"suggested that the use of BP should be discussed for all postmenopausal patients with early breast cancer who are indicated for adjuvant therapy.Recommended drugs included zoledronate,clodronate,and ibandronate,and the recommended duration of BP was 2-3 years.Owing to the inconsistent results of the ABCSG-18 and D-CARE trials and the lack of data directly comparing denosumab with BP in early breast cancer,the use of denosumab in adjuvant therapy was not recommended.In conclusion,the role of BP in the adjuvant treatment of early breast cancer has been further affirmed,while the value of denosumab remains unclear.关键词
乳腺癌/骨调节剂/双膦酸盐/辅助治疗Key words
Breast cancer/Bone-modifying agent(BMA)/Bisphosphonates(BP)/Adjuvant treatment分类
医药卫生引用本文复制引用
陆裕杰,朱思吉..《双磷酸盐和其他骨调节剂在乳腺癌辅助治疗中的应用:ASCO-OH(CCO)指南更新》解读[J].外科理论与实践,2024,29(5):405-408,4.基金项目
上海交通大学"交大之星"计划医工交叉研究基金(YG2024QNB05) （YG2024QNB05）
