心周脂肪组织体积与冠心病患者动脉僵硬度及血清炎症因子的相关性OACSTPCD

Objective To investigate the correlation of pericardial adipose tissue volume(PATV)with arterial stiffness and serum inflammatory factors in patients with coronary heart disease(CHD).Methods A total of 119 CHD patients admitted to Kailuan General Hospital,Tangshan Maternal and Child Health Hospital,and Leting County Hospital from May 2021 to May 2023 were selected as the CHD group,and 60 healthy individuals undergoing physical examinations during the same period were selected as the control group.Based on brachial-ankle pulse wave velocity(baPWV),the CHD group was further divided into a mild stiffness group(68 cases)and a severe stiffness group(51 cases).All subjects underwent multi-slice spiral CT scanning to measure PATV.Arteriosclerosis detector was used to measure baPWV,and serum inflammatory factors,including C-reactive protein(CRP),matrix metalloproteinase-9(MMP-9),and lipoprotein-associated phospholipase A2(LpPLA2)were detected using enzyme-linked immunosorbent assay(ELISA).The levels of PATV,baPWV,CRP,MMP-9,and LpPLA2 were compared between the CHD group and the control group,as well as between the mild and severe stiffness groups.Clinical data were also compared between the mild group and severe stiffness group.Pearson's correlation analysis was used to examine the relationships between PATV and baPWV as well as inflammatory factors in CHD patients.Logistic regression analysis was applied to identify factors influencing severe arterial stiffness in CHD patients.Results Compared with the control group,the levels of PATV,baPWV,CRP,MMP-9 and LpPLA2 in CHD group were increased(t=19.728,23.340,24.716,6.684,9.670;P<0.05).Among the 119 CHD patients,the rate of severe arterial stiffness was 42.86%.Compared with the mild stiffness group,the levels of PATV,baPWV,CRP,MMP-9 and LpPLA2 were increased in the severe stiffness group(t=6.141,25.339,8.715,6.176,5.886;P<0.05).Pearson's correlation analysis showed that PATV was positively correlated with baPWV,CRP,MMP-9 and LpPLA2 in CHD patients(r=0.600,0.469,0.504,0.537;P<0.05).There were statistically significant differences between the severe and mild stiffness groups in terms of age,hypertension,diabetes,and hyperlipidemia(t/χ2=3.363,5.287,4.615,4.236;P<0.05).Logistic regression analysis showed that age,hypertension,PATV,CRP,MMP-9,and LpPLA2 were risk factors for severe stiffness in CHD patients(OR=1.815,2.492,2.067,2.261,1.642,1.952;P<0.05).Conclusion Age,hypertension,PATV,CRP,MMP-9,and LpPLA2 are risk factors for severe arterial stiffness in CHD patients.