摘要
Abstract
Objective To analyze the serum levels of heat shock protein 47(HSP47)and soluble Fms-like tyrosine kinase 1(sFlt-1)in patients with stable angina and their correlation with the severity of coronary artery disease.Methods A total of 85 patients with stable angina treated in Qinghai Red Cross Hospital from May 2021 to May 2023 were selected as the stable angina group,and 85 healthy individuals who underwent physical examinations from the same hospital during the same period were regarded as the control group.Based on the degree of coronary artery stenosis,the stable angina group was divided into a mild stenosis group(36 cases),a moderate stenosis group(32 cases),and a severe stenosis group(17 cases).Additionally,based on the number of diseased coronary vessels,the stable angina group was divided into a three-vessel disease group(28 cases),a two-vessel disease group(32 cases),and a single-vessel disease group(25 cases).Serum expression levels of HSP47 and sFlt-1 were detected by enzyme-linked immunosorbent assay(ELISA),and compared among groups.The severity of coronary artery disease was assessed using the Gensini score,and the correlations between HSP47 and sFlt-1 levels and the Gensini score were analyzed using Spearman's correlation.Multiple logistic regression analysis was used to analyze the relationships between serum HSP47 and sFlt-1 levels and the Gensini score.Results Compared with the control group,patients in the stable angina group had higher levels of hypertension,hyperlipidemia,total cholesterol,C-reactive protein,triglyceride,homocysteine,low-density lipoprotein cholesterol,HSP47,and sFlt-1,and lower high-density lipoprotein cholesterol level(t/χ2=6.024,4.628,2.388,5.380,2.125,5.682,2.169,7.972,9.747,2.460;P<0.05).The levels of HSP47 and sFlt-1 in mild stenosis group,moderate stenosis group and severe stenosis group were increased successively(P<0.05).The levels of HSP47 and sFlt-1 in single-vessel disease group,two-vessel disease group and three-vessel disease group were increased successively(P<0.05).HSP47 and sFlt-1 levels were positively correlated with the Gensini score(r=0.538,0.641;P<0.01).Multiple logistic regression analysis showed that HSP47 and sFlt-1 levels were independent influencing factors of the Gensini score(OR=3.971,3.508;P<0.01).Conclusion Serum levels of HSP47 and sFlt-1 in patients with stable angina are elevated and correlated with the severity of coronary artery disease.关键词
稳定性心绞痛/热休克蛋白47/可溶性Fms样酪氨酸激酶1/冠状动脉病变严重程度Key words
Stable angina/Heat shock protein 47/Soluble Fms-like tyrosine kinase 1/Severity of coronary artery disease
