针刺研究2025，Vol.50Issue(2)：183-189,7.DOI:10.13702/j.1000-0607.20231040
补肾通督外治法治疗肾阳亏虚型强直性脊柱炎的疗效观察
Clinical observation on treatment of patients with kidney-yang deficiency type ankylosing spondylitis by using Bushen Tongdu external treatment
摘要
Abstract
Objective To observe and evaluate the effectiveness and safety of Bushen Tongdu(reinforcing the kidney-yang and regulating the Governor Vessel)external treatment for patients with kidney-yang deficiency type ankylosing spondylitis(AS).Methods Patients with Kidney-yang deficiency type AS were randomly divided into an observation group(36 cases,4 cases dropped out)and a control group(36 cases,3 cases dropped out).The observation group were received the Bushen Tongdu external treatment which was a combination of Ren Du Zhou-Tian moxibustion and acupoint embedding therapy,i.e.performing ginger-juice soaked nonwoven separated moxibustion first at the back covering the region from Dazhui(GV14)to Yaoshu(GV2)for 1 h,and then at the thoracoabdominal region covering the part from Tiantu(CV22)to Zhongji(CV3)for 1 h,followed by performing acupoint catgut embedding at one or two pairs of GV14,Shenshu(BL23),Dachangshu(BL25),Xuehai(SP10),and Zusanli(ST36),once a week,for 8 weeks.The control group received oral administration of salazosulfapyridine capsules(0.2 g/time),once a day for 8 weeks.Changes of the patients'conditions were evaluated by using traditional Chinese medicine(TCM)syndrome score(0 to 3 points for cold and painful lower back,morning stiffness,limited lumbar movement,soreness and weakness of waist and knees,etc.)and the total score(0 to 18 points),the Bath ankylosing spondylitis disease activity index(BASDAI)score(0 to 10 points for fatigue,physical discomfort caused by pain,swelling,or tenderness in the spine and peripheral joints,duration and severity of morning stiffness,etc).The therapeutic effect was assessed.The safety observation included fainting during acupuncture or moxibustion treatment,burn,etc.The contents of serum interleukin-6(IL-6),tumor necrosis factor-alpha(TNF-α),and matrix metalloproteinase-3(MMP-3)were detected before and after the treatment.Results After 8 weeks of treatment,the TCM syndrome score,total score,BASDA score,contents of serum IL-6,TNF-α and MMP-3 were strikingly decreased in both groups compared with those of their own pre-treatment(P<0.05),and the therapeutic effect of the observation group was significantly superior to that of the control group in lowering the scores of cold and painful lower back,weakness in the lower back and knees,preference for warmth and aversion to cold,pain worsened by cold,and total score,BASDA score,and contents of serum IL-6,TNF-α and MMP-3(P<0.05).The total effective rate of observation group was 90.63%(29/32),which was higher(P<0.05)than that of control group(75.76%,25/33).Conclusion The Bushen Tongdu external treatment method significantly improves AS patients'TCM clinical symptoms,alleviates inflammatory reactions,and demonstrates a significant efficacy with good safety.关键词
补肾通督外治法/强直性脊柱炎/任督周天灸/穴位埋线/肾阳亏虚Key words
Bushen Tongdu external treatment method/Ankylosing spondylitis/Ren Du Zhou-Tian moxibustion/Acupoint embedding therapy/Kidney-yang deficiency引用本文复制引用
周星宇,王新义,张玉飞,王晓龙,张秀秀,刘圆圆,李鹏燕,田元生..补肾通督外治法治疗肾阳亏虚型强直性脊柱炎的疗效观察[J].针刺研究,2025,50(2):183-189,7.基金项目
河南省科技攻关项目(No.162102310371) （No.162102310371）
2019年度河南省中医院科学研究专项课题(No.2019ZYBJ27) （No.2019ZYBJ27）
2021年第二批国家中医临床研究基地科研专项项目(No.2021JDZX2134) （No.2021JDZX2134）
河南省中医药青苗人才培养项目(No.豫卫中医函[2021]16号) （No.豫卫中医函[2021]16号）
