针刺研究2025，Vol.50Issue(2)：190-196,7.DOI:10.13702/j.1000-0607.20231101
经皮耳迷走神经刺激联合患者静脉自控镇痛对全膝关节置换术患者术后疼痛的影响
Effect of transcutaneous auricular vagus nerve stimulation combined with patient-controlled intravenous analgesia on postoperative pain in patients with total knee arthroplasty
摘要
Abstract
Objective To explore the effect of transcutaneous auricular vagus nerve stimulation(taVNS)combined with patient-controlled intravenous analgesia(PCIA)on postoperative pain in patients undergoing total knee arthroplasty(TKA).Methods A total of 140 patients with TKA were randomly divided into the taVNS group(n=70,with 5 dropped-out)and the sham stimulation group(n=70,with 6 dropped-out).The taVNS group received taVNS at the left ear conchae combined with PCIA treatment,while the sham stimulation group received sham taVNS at the left ear conchae combined with PCIA treatment.The time-weighted average(TWA)pain score,visual analogue scale(VAS)score of 1-7 days after surgery,the occurrence of adverse reactions such as nausea,vomiting,skin pruritus,drowsiness,respiratory depression,and the number of PCIA pump compressions within 48 hours after surgery were observed and compared between the 2 groups.The Beck Anxiety Inventory(BAI)scores,Bake Depression Inventory(BDI)scores,and Pittsburgh Sleep Quality Index(PSQI)scores were obtained on the day before surgery and 7 days after surgery.Results Compared with the sham stimulation group,the TWA pain score of the taVNS group was significantly decreased at the 7th day postoperatively(P<0.01),and the VAS scores of the taVNS group were significantly lower than those of the sham stimulation group on postoperative days 3rd,4th,and 5th(P<0.001,P<0.01,P<0.05),with no statistical significance in VAS scores on postoperative days 1st,2nd,6th,and 7th.Compared with the sham stimulation group,the incidence of nausea and the number of PCIA pump compressions within 48 hours after surgery in the taVNS group was significantly decreased(P<0.05).There was no statistical significance in the differences between the BDI,BAI,and PSQI scores before and after surgery in both groups.PSQI scores in the sham stimulation group and taVNS group were significantly lower than those in the same group 1 day before surgery(P<0.01,P<0.001).Conclusion The taVNS combined with PCIA can reduce postoperative pain,the incidence of nausea,and the opioid dosage in TKA patients.关键词
经皮耳迷走神经刺激/术后镇痛/患者静脉自控镇痛/全膝关节置换术Key words
Transcutuneous auricular vagus nerve stimulation/Postoperative analgesia/Patient-controlled intravenous analgesia/Total knee arthroplasty引用本文复制引用
黄豪逊,王行何,张妍,张瑾,李腾,王子恒,朱杨子,王立伟..经皮耳迷走神经刺激联合患者静脉自控镇痛对全膝关节置换术患者术后疼痛的影响[J].针刺研究,2025,50(2):190-196,7.基金项目
江苏省医学重点学科建设基金资助项目(No.JSDW202231) （No.JSDW202231）
江苏省老年健康科研项目(No.LKZ2023016) （No.LKZ2023016）
徐州市彭城英才项目(No.XWRCSL20220135) （No.XWRCSL20220135）
