金黄色葡萄球菌噬菌体的特性及其在畜牧业中的应用OA北大核心

As a natural antibacterial substance,bacteriophage has the advantages of easy access,low mutation rate,small adverse reactions,high specificity,high efficiency,and no harm to commensal bacteria,and can be used as the preferred drug to replace antibiotics.The host range of bacteriophage is a key indicator to evaluate the therapeutic po-tential of bacteriophages,and is of great significance for the selection of bacteriophages,the formulation of treatment strategies and the final efficacy,which is mainly determined by the receptor-binding proteins of the phage and the spe-cific receptors on the surface of the host cells.In this paper,the classification structure of Staphylococcus aureus phages,receptor-binding proteins,the discovery of host surface homologous receptors,and the application of bacterio-phage therapy in animal husbandry were expounded,in order to provide reference for the prevention and control of Staphylococcus aureus disease.