中国当代儿科杂志2025，Vol.27Issue(2)：176-183,8.DOI:10.7499/j.issn.1008-8830.2405030
基于Z值回归模型诊断儿童冠状动脉病变的研究
Diagnosis of coronary artery lesions in children based on Z-score regression model
摘要
Abstract
Objective To construct a Z-score regression model for coronary artery diameter based on echocardiographic data from children in Sichuan Province and to establish a Z-score calculation formula.Methods A total of 744 healthy children who underwent physical examinations at Sichuan Provincial People's Hospital from January 2020 to December 2022 were selected as the modeling group,while 251 children diagnosed with Kawasaki disease at the same hospital from January 2018 to December 2022 were selected as the validation group.Pearson correlation analysis was conducted to analyze the relationships between coronary artery diameter values and age,height,weight,and body surface area.A regression model was constructed using function transformation to identify the optimal regression model and establish the Z-score calculation formula,which was then validated.Results The Pearson correlation analysis showed that the correlation coefficients for the diameters of the left main coronary artery,left anterior descending artery,left circumflex artery,and right coronary artery with body surface area were 0.815,0.793,0.704,and 0.802,respectively(P<0.05).Among the constructed regression models,the power function regression model demonstrated the best performance and was therefore chosen as the optimal model for establishing the Z-score calculation formula.Based on this Z-score calculation formula,the detection rate of coronary artery lesions was found to be 21.5%(54/251),which was higher than the detection rate based on absolute values of coronary artery diameter.Notably,in the left anterior descending and left circumflex arteries,the detection rate of coronary artery lesions using this Z-score calculation formula was higher than that of previous classic Z-score calculation formulas.Conclusions The Z-score calculation formula established based on the power function regression model has a higher detection rate for coronary artery lesions,providing a strong reference for clinicians,particularly in assessing coronary artery lesions in children with Kawasaki disease.关键词
川崎病/冠状动脉病变/冠状动脉/Z值/超声心动图/儿童Key words
Kawasaki disease/Coronary artery lesion/Coronary artery/Z-score/Echocardiography/Child引用本文复制引用
王永,彭茜,蒋佳颖,邓燕,李波,帅平,胡小平,张银滟,吴寒,叶露薇..基于Z值回归模型诊断儿童冠状动脉病变的研究[J].中国当代儿科杂志,2025,27(2):176-183,8.基金项目
四川省人民医院科研基金资助项目(2021ZX07) （2021ZX07）
四川省卫生与计生委课题(150197). （150197）
