中国肺癌杂志2024，Vol.27Issue(12)：894-902,9.DOI:10.3779/j.issn.1009-3419.2024.101.32
支气管肺泡灌洗液中免疫细胞亚群与晚期非小细胞肺癌一线免疫治疗疗效相关性的分析:一项病例对照研究
Analysis of the Correlation between Immune Cell Subsets in Bronchoalveolar Lavage Fluid and the Efficacy of First-line Use of Immunotherapy in Advanced Non-small Cell Lung Cancer:A Case-control Study
摘要
Abstract
Background and objective Immunotherapy has been a standard treatment for the patients with ad-vanced non-small cell lung cancer(NSCLC),however,reliable biomarkers for predicting the response remain unclear.This study explores the subpopulations of lymphocytes in bronchoalveolar lavage fluid(BALF)and combines clinical and labo-ratory examination indicators of NSCLC patients to identify potential biomarkers related to immunotherapy.Methods A retrospective analysis was conducted on 82 patients with locally advanced or metastatic NSCLC who underwent electronic bronchoscopy and received first-line immunotherapy at Beijing Chest Hospital,Capital Medical University between March 2020 and November 2022.Logistic regression and random forest models were employed to determine the correlation between immune cell subsets in BALF and response of immunotherapy.The predictive value was validated by the model.Results All patients enrolled received first-line immunotherapy,and the efficacy was evaluated according to clinical guidelines:among the 82 patients included,48 patients got objective response and the other 34 did not achieve.The relationship between collected indicators and the best clinical treatment response was analyzed.The result shows that a higher percentage of total lymphocytes in BALF was associated with good response of first-line immunotherapy(P<0.05),while a higher percentage of T helper cells in BALF was associated with poor prognosis(P<0.05).Conclusion The proportions of total lymphocytes and T helper cells in BALF could be used as predictive biomarkers for first-line immunotherapy in late stage NSCLC.A multivariable model im-proves predictive accuracy.关键词
肺肿瘤/肺泡灌洗液/免疫治疗/疗效预测Key words
Lung neoplasms/Bronchoalveolar lavage fluid/Immunotherapy/Efficacy prediction引用本文复制引用
张凯,史亮,张同梅,仝丽,魏嵩,李红霞..支气管肺泡灌洗液中免疫细胞亚群与晚期非小细胞肺癌一线免疫治疗疗效相关性的分析:一项病例对照研究[J].中国肺癌杂志,2024,27(12):894-902,9.基金项目
本研究受北京市结核病胸部肿瘤研究所能力提升项目、北京市属医学科研院所公益发展改革试点项目(No.JYY2023-14、No.JYY2023-15)和北京微爱公益基金会-菁英科研基金(No.JYKY2024-0100307015)资助 This study was supported by the grants from Beijing Tuberculosis&Thoracic Tumor Research Institute,Project of Improvement(to Hongxia LI),Beijing Municipal Medical Research Institute Public Welfare Development Reform Pilot Project(No.JYY2023-14,No.JYY2023-15)(Both to Tongmei ZHANG)and Beijing Weiai Foundation-Elite Research Fund(No.JYKY2024-0100307015)(to Hongxia LI). （No.JYY2023-14、No.JYY2023-15）
