中国肺癌杂志2024，Vol.27Issue(12)：940-946,7.DOI:10.3779/j.issn.1009-3419.2024.102.45
晚期肺癌中ALK活化型改变与靶向治疗的研究进展
Research Progress of ALK Activation Pattern Changes and Targeted Therapy in Advanced Lung Cancer
魏澳娇 1江波 2黄玉蓉 1刘梦云 1严婧 3赵媛媛 4何文杰2
作者信息
- 1. 650500 昆明,昆明医科大学||650118 昆明,昆明医科大学第三附属医院老年肿瘤科
- 2. 650118 昆明,昆明医科大学第三附属医院老年肿瘤科
- 3. 650500 昆明,昆明医科大学||650032 昆明,昆明医科大学第一附属医院血液科
- 4. 650500 昆明,昆明医科大学||650032 昆明,昆明医科大学第一附属医院呼吸与危重症医学科
- 折叠
摘要
Abstract
Lung cancer is the most common cancer in China and even in the world,and it is also the main cause of cancer death.Patients with anaplastic lymphoma kinase(ALK)gene alterations have the opportunity to receive molecularly targeted therapies.The inhibitors of anaplastic lymphoma kinase,such as ALK-tyrosine kinase inhibitors(ALK-TKIs)signifi-cantly prolong the survival of patients.ALK gene variant types include point mutation,amplification,fusion/rearrangement,and ALK fusion is more common than other types.However,the effect of different types of gene changes in molecular targeted therapy is different.Therefore,this paper introduced the relevant contents of different variants of ALK gene,focused on the re-search progress of targeted therapy,and proposed the future development direction.关键词
肺肿瘤/间变性淋巴瘤激酶/间变性淋巴瘤激酶活化型改变/间变性淋巴瘤激酶抑制剂/靶向治疗Key words
Lung neoplasms/Anaplastic lymphoma kinase/Anaplastic lymphoma kinase activation patten change/Anaplastic lymphoma kinase inhibitors/Targeted therapy引用本文复制引用
魏澳娇,江波,黄玉蓉,刘梦云,严婧,赵媛媛,何文杰..晚期肺癌中ALK活化型改变与靶向治疗的研究进展[J].中国肺癌杂志,2024,27(12):940-946,7.
