中国免疫学杂志2025，Vol.41Issue(2)：484-489,6.DOI:10.3969/j.issn.1000-484X.2025.02.039
TLR5在肥胖相关高血压发病机制中的作用:现有证据和未来挑战
Role of TLR5 in pathogenesis of obesity-related hypertension:Current evidence and future challenges
摘要
Abstract
Toll-like receptor 5(TLR5)is a pattern recognition receptor,the main extracellular receptor for recognizing flagel-lin,and a bridge between innate and adaptive immunity.It can activate innate immunity and induce the release of a series of down-stream cytokines,as well as play an important role in protecting the host from flagellated pathogens and establishing immune tolerance.These functions are related to the pathogenesis of obesity hypertension in various aspects.This article aims to review the relationship between TLR5 and obese hypertension,as well as the new progress on the interaction between TLR5 and flagellin structure and func-tion,and discuss the future research directions and challenges.关键词
Toll样受体5/高血压/肥胖/肠道菌群/免疫耐受Key words
Toll-like receptor 5/Hypertension/Obesity/Intestinal microbiota/Immune tolerance分类
医药卫生引用本文复制引用
吴欧,芈肖肖,张虎,袁承达,高锦..TLR5在肥胖相关高血压发病机制中的作用:现有证据和未来挑战[J].中国免疫学杂志,2025,41(2):484-489,6.基金项目
国家自然科学基金资助项目(82100614). （82100614）
