中国免疫学杂志2025，Vol.41Issue(2)：490-494,5.DOI:10.3969/j.issn.1000-484X.2025.02.040
外泌体在过敏原免疫治疗中的研究进展
Research progress of exosomes in allergen immunotherapy
摘要
Abstract
Exosomes are extracellular vesicles secreted by cells with lipid bilayer structure.As an important carrier of intercel-lular communication,exosomes are involved in regulating various pathological and physiological processes of the body.Exosomes can be used by immune cells to enhance or suppress immune response,and exosomes play an important role in allergic sensitization and in-flammation,in which mast cell-derived exosomes can absorb IgE and down-regulate IgE levels in the whole body.Tolerogenic exo-somes can inhibit allergic immune response by inducing regulatory T cells.Exosomes promote Th1 response to allergens;exosomes can also regulate IgE to promote antigen presentation,so exosomes are one of the development directions of immunotherapy.This article reviews the relationship between exosomes and allergic diseases and the progress in allergen specific immunotherapy.关键词
外泌体/过敏原/过敏性疾病/过敏原免疫治疗Key words
Exosomes/Allergy/Allergic diseases/Allergen immunotherapy分类
医药卫生引用本文复制引用
邓健健,邱艺,杨春平..外泌体在过敏原免疫治疗中的研究进展[J].中国免疫学杂志,2025,41(2):490-494,5.基金项目
国家自然科学基金项目(81760183,82160211) （81760183,82160211）
江西省自然科学基金项目(20202ACBL206013) （20202ACBL206013）
江西省科技厅应用研究培育计划(20212BAG70031). （20212BAG70031）
