中国免疫学杂志2025，Vol.41Issue(2)：495-502,8.DOI:10.3969/j.issn.1000-484X.2025.02.041
中药单体皂苷类调控免疫细胞抗肿瘤作用机制的研究进展
Research progress on mechanism of monomeric saponins in Chinese herbal medicine in anti-tumor immunity
摘要
Abstract
The incidence and mortality rates of malignant tumors continue to rise,which posing a serious threat to the physical and mental health of the global population,and becoming a significant scientific problem in urgent need of resolution.Tumor immuno-therapy,as a novel anti-tumor treatment,optimizes the treatment modalities for tumors.Currently,combination of immunotherapy with chemotherapy and targeted therapy has shown promising results in anti-tumor treatment.Traditional Chinese medicine is widely used in comprehensive anti-tumor treatments,demonstrating significant effectiveness and distinct advantages.Among them,monomeric saponins in Chinese herbal medicine exhibit remarkable anti-tumor effects with the notable advantages of high efficiency and low tox-icity.This has made them a focal point of research for many oncologists.Studies have revealed that a large number of monomeric sapo-nins from Chinese herbal medicine can directly or indirectly affect the functions of immune cells by regulating the innate immune sys-tem,adaptive immune system,and related immune cell factors.This enhances the immune cytotoxicity against tumor cells,thereby better exerting the anti-tumor immune effects.This paper summarizes the research findings on the anti-tumor effects of monomeric sapo-nins in recent years.It elaborates on the specific mechanisms by which monomeric saponins from Chinese herbal medicine regulate im-mune cells to exert anti-tumor effects.The aim of this paper is to provide new research perspectives for tumor immunotherapy,further harness the crucial role of traditional Chinese medicine in anti-tumor treatment,and propel the modernization of traditional Chinese medicine.关键词
皂苷类/免疫细胞/抗肿瘤/研究进展Key words
Saponins/Immune cells/Anti tumor/Research progress分类
医药卫生引用本文复制引用
赫名扬,王成志,张晓青,李东东,刘培民..中药单体皂苷类调控免疫细胞抗肿瘤作用机制的研究进展[J].中国免疫学杂志,2025,41(2):495-502,8.基金项目
国家自然科学基金资助项目(82204981) （82204981）
河南省中医药科学研究专项(2021JDZX2002,20-21ZY2115) （2021JDZX2002,20-21ZY2115）
河南省中医药大学2022年度研究生科研创新能力提升计划(2022KYCX057). （2022KYCX057）
