中国免疫学杂志2025，Vol.41Issue(2)：510-512,后插1-后插2,5.DOI:10.3969/j.issn.1000-484X.2025.02.043
TRAF6泛素化调控功能与类风湿关节炎发病机制的研究进展
Research progress on ubiquitin regulation function of TRAF6 and pathogenesis of rheumatoid arthritis
摘要
Abstract
Rheumatoid arthritis(RA)is a common autoimmune disease with synovitis as core pathological manifestation,with strong injury and high disability rate,which can not be cured completely at present.Recent studies have shown that tumor necro-sis factor receptor-related factor 6(TRAF6),as a ubiquitin ligase E3,plays a key role in autoimmune diseases and inflammatory diseases through a variety of pathways.This article reviews structure,function,ubiquitin regulation of TRAF6 and research progress of pathogenesis of RA.关键词
类风湿关节炎/TRAF6/泛素化/信号通路Key words
Rheumatoid arthritis/TRAF6/Ubiquitin/Signal pathway分类
医药卫生引用本文复制引用
张小娜,杜小正,袁博,李福欣,刘莉梅..TRAF6泛素化调控功能与类风湿关节炎发病机制的研究进展[J].中国免疫学杂志,2025,41(2):510-512,后插1-后插2,5.基金项目
国家自然科学基金(82060891) （82060891）
甘肃省青年科技基金(20JR10RA344) （20JR10RA344）
甘肃省皇甫谧针灸医院科研孵化项目(02) （02）
国家中医药管理局甘肃郑氏针法学术流派传承工作室项目(2305135901). （2305135901）
