中国实用儿科杂志2025，Vol.40Issue(1)：54-59,6.DOI:10.19538/j.ek2025010609
纯母乳喂养不同排便频次婴儿粪便胆汁酸成分检测及其意义
Detection of fecal bile acid components in exclusively breastfed infants with different defecation frequencies and its significance
摘要
Abstract
Objective To study the correlation between the changes in the content of individual bile acid components in the feces of infants who are exclusively breastfed and the frequency of defecation,in order to find the differential metabolites of bile acid which regulate the defecation frequencies of infants and provide beneficial suggestions for clinical intervention.Methods Totally 102 healthy,full-term,exclusively breastfed infants aged 0.5-6 months were selected,who underwent health consultations and regular check-ups at the Pediatric Outpatient and Preventive Health Care Department of the First Affiliated Hospital of Kunming Medical University from September 2022 to May 2023.Fecal specimens were collected from these infants and categorized into three groups based on different defecation frequencies.The groups included the increased defecation frequency group(defecating more than 3 times per day,Group A,n=34),the decreased defecation frequency group(defecating once in more than 3 days or needing assistance to defecate,Group B,n=32),and the control group(defecating less than or equal to 3 times per day or defecating once within 3 days,Group C,n=36).The content of bile acids was detected in feces by UPLC-MS/MS.Results Chenodeoxycholic acid levels were significantly higher in group A than in groups C and B(P＜0.017),Ursodeoxycholic acid levels were significantly higher in group B than in groups C and A(P＜0.017).The difference in deoxycholic acid and lithocholic acid were statistically significant between group A and group B(P＜0.017).When comparing the levels of cholic acid and glycochenodeoxycholic acid among the three groups,no statistically significant difference was found.Conclusion Chenodeoxycholic acid and ursodeoxycholic acid may serve as potential differential metabolites associated with increased or decreased defecation frequency in exclusively breastfed infants.关键词
母乳喂养/婴儿/排便频次/粪便代谢物/胆汁酸Key words
breastfeeding/infants/defecation frequency/fecal metabolites/bile acids分类
医药卫生引用本文复制引用
贺成慧,黄永坤,单子鸿,何青青,阳情姚,陈艳,张园园,李檬,熊晶晶,李湛华..纯母乳喂养不同排便频次婴儿粪便胆汁酸成分检测及其意义[J].中国实用儿科杂志,2025,40(1):54-59,6.基金项目
国家自然科学基金项目(81960102) （81960102）
