中国畜牧杂志2025，Vol.61Issue(2)：50-54,5.DOI:10.19556/j.0258-7033.20240608-03
类泛素化修饰在卵母细胞减数分裂过程中的作用研究进展
Advances in the Role of Sumoylation Modification in Oocytes Meiosis
摘要
Abstract
Ubiquitin-like modifications(SUMOylation)constitute a crucial type of protein post-translational modifications(PTMs)in mammals.SUMOylation involves the Small Ubiquitin-Related Modifier(SUMO)family,various SUMO modifying enzymes,and specific SUMO proteases.SUMOylation serves a significant regulatory function in cellular physiological processes.Studies have revealed that reduced SUMOylation of centromere-related proteins in oocytes leads to premature separation of numerous sister chromatids.Additionally,decreased SUMOylation of spindle-related proteins can cause spindle disorders in oocytes during the second meiotic metaphase.This article reviews SUMOylation and its impacts on the centromere and spindle during oocyte meiosis,aiming to offer a theoretical foundation for mitigating reproductive disorders in female animals.关键词
卵母细胞/减数分裂/SUMO化修饰/着丝点/纺锤体Key words
Oocytes/Meiosis/Sumoylation/Centromere/Spindle body分类
农业科技引用本文复制引用
刘航瑀,陈璇..类泛素化修饰在卵母细胞减数分裂过程中的作用研究进展[J].中国畜牧杂志,2025,61(2):50-54,5.基金项目
延边大学博士启动基金(602024044) （602024044）
