中国医药科学2025，Vol.15Issue(1)：19-22,4.DOI:10.20116/j.issn2095-0616.2025.01.05
乙型肝炎肝硬化患者肠道菌群水平与TC、TG、HDL-C及LDL-C水平的关系分析
Analysis of the relationship between the levels of intestinal flora and the levels of TC,TG,HDL-C and LDL-C in patients with hepatitis B cirrhosis
摘要
Abstract
Objective To explore the relationship between intestinal flora and the levels of total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C)and low-density lipoprotein cholesterol(LDL-C)in patients with hepatitis B cirrhosis(HBC).Methods HBC patients(cirrhosis group)and hepatitis B patients(hepatitis B group)treated in the Department of Infectious Disease of the No.923 Hospital of the Joint Logistic Support Force from July 2021 to June 2022,and healthy subjects who had a physical examination at the Physical Examination Center(control group)were selected,with 80 cases in each group.The levels of intestinal flora and indicators of glycolipid metabolism were detected and compared between the groups,and the relationship between the two was analyzed.Results The levels of Enterobacteriaceae and Enterococcus were the highest in the cirrhosis group,and the levels of Enterobacteriaceae and Enterococcus were higher in the hepatitis B group than in the control group,with statistically significant differences(P＜0.05).The levels of Bifidobacterium and Lactobacillus were the lowest in the cirrhosis group,and the levels of Bifidobacterium and Lactobacillus were lower in the hepatitis B group than in the control group,with statistically significant differences(P＜0.05).Fasting blood glucose(FBG),TC,TG and LDL-C levels were the highest in the cirrhosis group,and FBG,TC,TG and LDL-C levels were higher in the hepatitis B group than in the control group,with statistically significant differences(P＜0.05).HDL-C levels were the lowest in the cirrhosis group,and HDL-C levels were lower in the hepatitis B group than in the control group,with statistically significant differences(P＜0.05).Enterobacteriaceae and Enterococcus were all positively correlated with FBG,TC,TG and LDL-C,and negatively correlated with HDL-C.Bifidobacterium and Lactobacillus were all negatively correlated with FBG,TC,TG and LDL-C and positively correlated with HDL-C.Conclusion There is a strong relationship between the level of intestinal flora and the level of TC,TG,HDL-C,LDL-C in patients with HBC,which provides the possibility of using intestinal flora to treat related diseases in the future.关键词
乙型肝炎/肝硬化/肠道菌群/总胆固醇/甘油三酯/高密度脂蛋白胆固醇/低密度脂蛋白胆固醇/相关性Key words
Hepatitis B/Cirrhosis/Intestinal flora/Total cholesterol/Triglycerides/High-density lipoprotein cholesterol/Low-density lipoprotein cholesterol/Correlation分类
医药卫生引用本文复制引用
陆晖,谭可平,陈婵,覃国琦,陆鹏..乙型肝炎肝硬化患者肠道菌群水平与TC、TG、HDL-C及LDL-C水平的关系分析[J].中国医药科学,2025,15(1):19-22,4.基金项目
广西壮族自治区卫生健康委员会科研课题(Z20210601). （Z20210601）
